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l arginine/kanker
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Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity
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FIELD OF THE INVENTION
The present invention covers pharmaceutical compositions, and method for the treatment of cancer using substituted purinyl compounds. In particular, the present invention concerns 6-substituted purinyl alkoxycarbonyl amino acid compounds, more particularly arginine
Compositions of engineered human arginases and methods for treating cancer
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The sequence listing that is contained in the file named "GGEOP0002USC2_ST25.txt", which was created on Nov. 17, 2014, is filed herewith by electronic submission and is incorporated by reference herein.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention generally relates to
Compositions of engineered human arginases and methods for treating cancer
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention generally relates to compositions and methods for the treatment of cancer with enzymes that deplete L-Arginine in serum. In some embodiments, the cancer is one that does not express, or is otherwise deficient in, argininosuccinate
Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders
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FIELD OF THE INVENTION
The present invention relates to, inter alia, a novel crystalline free-plate habit or morphology, processes for preparing the crystalline free-plate habit, and uses of the crystalline free-plate habit of the L-arginine salt of
Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclo-penta [b]indol-3-yl)acetic acid(Compound 1) for use in SIPI receptor-associated disorders
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FIELD OF THE INVENTION
The present invention relates to, inter alia, a novel crystalline free-plate habit or morphology, processes for preparing the crystalline free-plate habit, and uses of the crystalline free-plate habit of the L-arginine salt of
Polyion complex of poly(L-arginine) segment-containing block copolymer and polyanionic polymer
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TECHNICAL FIELD
The present invention relates to a polyion complex (PIC) containing poly(ethylene glycol)-b-poly(L-arginine) or poly(L-arginine)-b-poly(ethylene glycol)-b-poly(L-arginine) and a polyanionic polymer, application of the PIC such as use thereof for activation of macrophages in tumor
Inhibiting furin with polybasic peptides
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This invention pertains to the inhibition of furin, which can be used in inhibiting certain bacterial infections, viral infections, and cancers.
Furin, a ubiquitous serine endoprotease, has been implicated in the activation of certain bacterial toxins and viral glycoproteins, as well as in the
Inhibiting furin with polybasic peptides
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This invention pertains to the inhibition of furin, which can be used in inhibiting certain bacterial infections, viral infections, and cancers.
Furin, a ubiquitous serine endoprotease, has been implicated in the activation of certain bacterial toxins and viral glycoproteins, as well as in the
Formulations of Factor VIIa inhibitors and utility
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FIELD OF THE INVENTION
The field relates to the use of novel nanoparticle formulations and chemical structures that include vasodilator Factor VIIa inhibitors to treat vascular disorders in a subject.
BACKGROUND OF THE INVENTION
Vascular endothelial-mediated disorders including sickle cell diseases,
Diagnostic assay and treatment for preeclampsia
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CROSS-REFERENCE TO RELATED APPLICATION
This application is a U.S. national entry application under 37 C.F.R. .sctn. 371(b) of International Application Serial No. PCT/GB2016/050408 filed Feb. 18, 2016, which claims the right of priority and benefit under 35 U.S.C. .sctn..sctn. 119 & 365 of GB
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