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15 resultaten
Method and compositions for treating malignant tumors and inhibiting growth and metastases of malignant tumors
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FIELD OF THE INVENTION
The present invention is directed to methods and compositions for treating malignant tumors and other metastatic diseases and for inhibiting the metastases of malignant tumors.
BACKGROUND OF THE INVENTION
The formation of metastases of malignant tumors, which initiate from a
Antibodies recognizing a carbohydrate containing epitope on CD-43 and CEA expressed on cancer cells and methods using same
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FIELD OF THE INVENTION
The present invention relates to novel monoclonal antibodies that recognize a carbohydrate containing epitope on CD43 and carcinoembryonic antigen (CEA) expressed on nonhematopoietic tumor or cancer cells. These antibodies have the property of inducing cell death (e.g.,
Antibodies recognizing a carbohydrate containing epitope on CD-43 and CEA expressed on cancer cells and methods using same
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FIELD OF THE INVENTION
The present invention relates to novel monoclonal antibodies that recognize a carbohydrate containing epitope on CD43 and carcinoembryonic antigen (CEA) expressed on nonhematopoietic tumor or cancer cells. These antibodies have the property of inducing cell death (e.g.,
Synthetic glycoamines and methods for their use that affect cell adhesion, inhibit cancer cell metastasis, and induce apoptosis
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FIELD OF THE INVENTION
The present invention relates to pharmaceuticals that affect cell adhesion, inhibit cancer cell metastasis, and induce apoptosis both in vitro and in vivo.
Background of the Invention
Cell adhesion is one important property that differentiates multi-cellular organisms from
Antracycline antineoplastic agents encapsulated in phospholipid vesicle particles and methods for using same for tumor therapy
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FIELD OF INVENTION
This invention relates to compositions consisting of phospholipid encapsulated anthracycline anti-neoplastic agents. In another aspect it relates to the use of such compositions to deliver chemotherapeutic agents to tumors in a body.
BACKGROUND
Daunorubicin (also known as
Doxorubicin formulations for anti-cancer use
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FIELD OF INVENTION
The present invention relates to improved formulations for injectable administering doxorubicin to cancer patients and improved methods of treatment for cancer patients based upon these formulations.
BACKGROUND
Doxorubicin is a known chemotherapeutic agent administered mainly by
Lyophilized preparation of cytotoxic dipeptides
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TECHNICAL FIELD
The present invention is directed to lyophilized pharmaceutical preparations comprising cytotoxic dipeptides or pharmaceutically acceptable salts thereof, methods for their preparation, compositions comprising the lyophilized pharmaceutical preparations and their use in the treatment
Lyophilized preparation of cytotoxic dipeptides
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TECHNICAL FIELD
The present invention is directed to lyophilized pharmaceutical preparations comprising cytotoxic dipeptides or pharmaceutically acceptable salts thereof, methods for their preparation, compositions comprising the lyophilized pharmaceutical preparations and their use in the treatment
Micronized tanaproget, compositions, and methods of preparing the same
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BACKGROUND OF THE INVENTION
Intracellular receptors (IR) form a class of structurally related gene regulators known as "ligand dependent transcription factors". The steroid receptor family is a subset of the IR family, including the progesterone receptor (PR), estrogen receptor (ER), androgen
Micronized tanaproget, compositions, and methods of preparing the same
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BACKGROUND OF THE INVENTION
Intracellular receptors (IR) form a class of structurally related gene regulators known as "ligand dependent transcription factors". The steroid receptor family is a subset of the IR family, including the progesterone receptor (PR), estrogen receptor (ER), androgen
Micronized tanaproget, compositions, and methods of preparing the same
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BACKGROUND OF THE INVENTION
Intracellular receptors (IR) form a class of structurally related gene regulators known as "ligand dependent transcription factors". The steroid receptor family is a subset of the IR family, including the progesterone receptor (PR), estrogen receptor (ER), androgen
Micronized tanaproget and compositions containing same
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BACKGROUND OF THE INVENTION
Intracellular receptors (IR) form a class of structurally related gene regulators known as "ligand dependent transcription factors". The steroid receptor family is a subset of the IR family, including the progesterone receptor (PR), estrogen receptor (ER), androgen
Solid dosage forms of oleyl phosphocholine
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The present invention relates to solid dosage forms of oleyl phosphocholine (C18:1-PC), or OlPC, for oral administration. Further, the present invention relates to methods for the preparation of the present solid dosage forms and the use thereof as a medicament and especially a medicament for the
N.sub.2S.sub.2 chelate-targeting ligand conjugates
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The benefit of the filing date of U.S. application Ser. No. 10/703,405, filed Nov. 7, 2003, and entitled "Ethylenedicysteine (EC)-Drug Conjugates, Compositions, and Methods for Tissue-Specific Disease Imaging" by David J. Yang, et al., which application in turn claims the benefit of U.S. provisional
Physiologically active peptides and a process for preparation thereof
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The following examples illustrate the present invention, but it is to be understood that they are given for the purpose of illustration and not limitation.
EXAMPLE 1
A medium (100 l) containing 6.0% soluble starch, 4.0% cotton seed meal, 0.2% (NH.sub.4).sub.2 SO.sub.4, 0.1% yeast extract, 0.2%
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