lanthanum/versterkte bloedingsneiging

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Gastrointestinal Nodules and Bleeding with Long-Term Lanthanum Use; DRESS and Hepatotoxicity Due to Rivaroxaban; Thrombocytopenia Induced by Pentoxifylline; Amlodipine-Induced Schamberg's Disease; Varenicline-Induced Acute Liver Injury.

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The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to

The Risk of Mistaking Intestinal Lanthanum Carbonate for Intestinal Bleeding on CT.

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Pre-existing oral contrast from lanthanum carbonate: a confounding factor in CT mesenteric angiography.

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A 69-year-old male was referred from the renal unit to radiology for investigation of bleeding per rectum. A CT mesenteric angiogram was performed. However, it was noted on the pre-contrast images that the large bowel contained positive oral contrast media. The procedure was abandoned as it would

Lanthanum phosphate binder-induced iron deficiency anaemia.

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Lanthanum carbonate is a phosphate binder that is used to reduce serum phosphate levels in patients with end-stage renal disease (ESRD). Lanthanum forms insoluble lanthanum phosphate complexes that are supposed to pass through the gastrointestinal (GI) tract unabsorbed. Phosphate binders have been

Effect of hemorrhagic shock on the performance, O2-consumption, and ultrastructure of isolated rat hearts.

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Rat hearts were isolated from control animals anesthetized and sham treated for 2.5 hours and following 2.5 hours of hemorrhagic hypotension and they were perfused by modified Langendorff technique. Hearts isolated following hemorrhagic hypotension exhibited increased coronary resistance, depressed

A Nodular Foreign Body Reaction in a Dialysis Patient Receiving Long-term Treatment With Lanthanum Carbonate.

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A 63-year-old man with HIV (human immunodeficiency virus) infection and end-stage renal disease, treated with lanthanum carbonate phosphate binder for 4 years, presented with anemia and an upper gastrointestinal bleed. Upper endoscopy revealed a nodular hyperplastic epithelium, with an endoscopic

Quantitative Visualization of Lanthanum Accumulation in Lanthanum Carbonate-Administered Human Stomach Tissues Using Mass Spectrometry Imaging

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Platinum, a transition metal that is widely used in anti-cancer agents, also results in the development of nephropathy due to severe adverse reactions caused by platinum-induced nephrotoxicity. Reports on imaging with metals other than platinum remain are limited, even in preclinical studies.

Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock.

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BACKGROUND The use of plasma-based resuscitation for trauma patients in hemorrhagic shock has been associated with a decrease in mortality. Although some have proposed a beneficial effect through replacement of coagulation proteins, the putative mechanisms of protection afforded by plasma are

Altered expression of ZO-1 and ZO-2 in Sertoli cells and loss of blood-testis barrier integrity in testicular carcinoma in situ.

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Carcinoma in situ (CIS) is the noninvasive precursor of most human testicular germ cell tumors. In normal seminiferous epithelium, specialized tight junctions between Sertoli cells constitute the major component of the blood-testis barrier. Sertoli cells associated with CIS exhibit impaired

The association of type II pneumocytes and endothelial permeability with the pulmonary custocyte system in experimental acute pancreatitis.

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BACKGROUND Pancreatitis-associated pulmonary injury is still associated with substantial mortality, especially when seen as a part of the multiple organ dysfunction syndrome. METHODS The present study aimed at evaluating alterations in type II pneumocytes and the potential relationship with the

Role of calcium channels in oxyhemoglobin-induced apoptosis in endothelial cells.

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OBJECTIVE Oxyhemoglobin (OxyHb) released from hemolysed erythrocytes has been considered to be responsible for cerebral vasospasm after subarachnoid hemorrhage. The authors previously reported that OxyHb produced apoptosis in cultured vascular endothelial cells. The change in intracellular Ca++

Morphological changes in acute cerebral ischemia after occlusion and reperfusion in the rat.

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Blood-brain barrier permeability was investigated in acute focal ischemia after MCA occlusion and reperfusion. Four kind of tracers were used: sodium fluorescein and ionic lanthanum as a small molecular tracer, and Evans blue and HRP as a macromolecular tracer. BBB permeability to the tracers was

Repair of outer blood-retinal barrier after severe ocular blunt trauma in rabbits.

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Retinal contusion is a leading cause of visual loss in ocular blunt trauma. However, its pathogenesis remains controversial. We established a rabbit model of severe retinal contusion with energy of about 2.87 J. Typical retinal edema and sometimes subretinal hemorrhage reproducibly occurred at the

[An experimental study of blast injury].

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This paper presents some aspects of the authors' experimental research on blast injury in the past two years. The main results are as follows: (1) A new designed 39 meter-long shock tube for biological test has been built in the laboratory. Its maximal overpressure values are 215 kPa (in open

Lonomia obliqua caterpillar venom increases permeability of the blood-brain barrier in rats.

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Human envenoming by caterpillars of the saturniid moth Lonomia obliqua in southern Brazil produces a mild local response (erythema, some edema, and pain) and systemic effects that include incoagulable blood, renal failure and in severe accidents intracerebral hemorrhage. In this work, we used light

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