Subjects in this arm will be given 3g/day of maca root for 12 weeks

Subjects in this arm will receive inactive placebo for 12 weeks.

Subjects in this arm will be given 3g/day of maca root for 12 weeks
Maca Root: 3g/day of Maca Root for 12 weeks.

Maca Root

Subjects in this arm will receive inactive placebo for 12 weeks.
Placebo: Placebo provided by research pharmacy daily for 12 weeks.

Placebo

Total

Sex: Female, Male

Region of Enrollment

Arizona Sexual Experience Scale (ASEX) consists of five items rating sexual drive, arousal, vaginal lubrication/penile erection, ability to reach orgasm, and satisfaction from orgasm.The range of total score is 5-30 with the higher scores indicating greater sexual dysfunction. A total final score of 10 or less is considered to indicate remission of sexual dysfunction.

Proportion of Participants in Remission Based on Arizona Sexual Experience Scale (ASEX) Score of 10 or Less After 12 Weeks of Treatment.

Massachusetts General Hospital-Sexual Functioning Questionnaire (MGH-SFQ) is composed of five items evaluating libido, sexual arousal or excitement, ability to achieve orgasm, ability to achieve and maintain an erection (for men only) and overall sexual satisfaction. Items are rated on a scale of 1 to 6 with a rating of 1 indicating greater than normal functioning and a rating of 6 indicating totally absent functioning. A total final score of 12 or less is considered to indicate remission of sexual dysfunction.

Proportion of Participants in Remission Based on Massachusetts General Hospital Sexual Functioning Questionnaire (MGH-SFQ) Score of 12 or Less After 12 Weeks of Treatment.

Overall Study

Dr. David Mischoulon, Director

Antidepressant Induced Sexual Dysfunction

Placebo provided by research pharmacy daily for 12 weeks.

Depression Clinical and Research Program, Massachusetts General Hospital

Study of Maca Root for the Treatment of Antidepressant-Induced Sexual Dysfunction in Females

A Double-Blind, Placebo Controlled Study of Maca Root for the Treatment of Antidepressant-Induced Sexual Dysfunction in Females

No current plan for this. In the event that other researchers inquire about using our data (e.g. in a meta-analysis), we will evaluate how to proceed.

David Mischoulon, MD, PhD

Physician

Massachusetts General Hospital

National Institutes of Health (NIH)

National Center for Complementary and Integrative Health (NCCIH)

A Healthy Alternative, LLC

Subjects were randomized in a double blind manner to maca root or placebo. Improvement in sexual functioning was compared between the two treatment groups.

Study subjects and investigator clinicians were blinded to the treatment assignment.

Patients receiving 1500mg of maca root
Maca Root

Maca Root 1500mg

Patients receiving 3000mg of maca root
Maca Root

Maca Root 3000mg

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Full title: Massachusetts General Hospital Sexual Dysfunction Inventory Minimum score for Men: 5 Minimum score for Women: 4 Maximum score for Men: 30 Maximum score for Women: 24
*One item on the measure is for men only
A score of a 5 (4 for women) indicates improvement in sexual function. A score of 10 (8 for women) indicates no change. A score higher than 10 (8 for women) indicates a level of sexual dysfunction.

lepidium/antidepressivum

Study of Maca Root for the Treatment of Antidepressant-Induced Sexual Dysfunction in Females

Safety and Effectiveness Study of Maca Root to Treat Antidepressant-Induced Sexual Dysfunction

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