dexmedetomidine 2ug.kg-1 over 10 min followed by 0.7ug.kg-1.h-1

61 subjects in group F received IV (1mcg/kg)as a bolus as soon as IV access was established.
0

Fentanyl (F) Group

61 subjects Group D received IV dexmedetomidine 2mcg/kg over 10 minutes followed by an infusion of 0.7mcg.kg/hr

Dexmedetomidine

Total

Sex: Female, Male

Region of Enrollment

emergence agitation and pain will be assessed. Pediatric Anesthesia Emergence Delirium Scale (PAED) range 0-20 a lower score indicates the child is calm and the higher score indicates severe agitation. Cole Agitation Scale was employed which is a 5 point Likert scale. Parameters ranging 1 to 5 1=child is calm and 5 =the child is severly agitated .
Objective Pain Score range is 0-10 (higher score the greater pain). 3 Parameters are captured systolic b/p,crying, movements, agitation , complaints of pain

Emergence Agitation and Pain

fentanyl bolus 1ug.kg-1
fentanyl: 1 microgram/kilogram as a bolus

Fentanyl

dexmedetomidine 2ug.kg-1 over 10 min followed by 0.7ug.kg-1.h-1
dexmedetomidine: 2 micrograms/kilogram as a bolus then 0.7 micrograms/kilogram infusion

Duration of Agitation

Participants whose heart rate per minute was below 60 intraoperatively. Participants whose systolic blood pressure dremonstrated < 30% decrease from baseline and sustained for 5 minutes received rescue as defined by the protocol.

Hemodynamic Stability

defined as spontaneous eye opening or on command

Time to Awaken

defined as time from end of surgery to tracheal extubation

Time to Extubation

Number of Participants With SpO2 < or Equal to 95%

Participants Requiring Morphine Rescue in PACU

Overall Study

Anuradha Patel, MD

No subjects in group F experienced an adverse event.
0

1 subjects Group D experienced an adverse event.

Obstructive Sleep Apnea

2 micrograms/kilogram as a bolus then 0.7 micrograms/kilogram infusion

malocclusion/misselijkheid

Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy

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