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11 resultaten
Fatal infantile cardiac glycogenosis without acid maltase deficiency presenting as congenital hydrops.
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[Anatomical and functional changes of the human small intestine induced by 5-fluorouracil (author's transl)].
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In 10 female patients with carcinoma the effect of a single dose of 5-fluorouracil on morphologic alterations of the small bowel mucosa, intestinal disaccharidase-activities and lactose-tolerance-test was studied pre- and 96 hours posttherapy. After having given a standard dose of 1,25-1,50 gr
Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs
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The present study is aimed to investigate the anti-inflammatory, antioxidant and antidiabetic activities of three series of hydroxytriazenes based on sulfa drugs viz; Sulphathiazole (ST), Sulfisoxazole (SF) and Sulphamethoxazole (SM). Antidiabetic activities of the synthesized hydroxytriazenes were
Jejunal transport in experimental nephrotic syndrome.
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In vivo jejunal transport of amino acids, monosaccharides, sodium, and electrolytes were studied in rats made nephrotic with puromycin aminonucleoside (PAN) and in pair-fed controls. Studies were performed 14 days after a single intravenous dose of PAN when rats were no longer edematous, but were
Optimal Solution Volume for Luminal Preservation: A Preclinical Study in Porcine Intestinal Preservation.
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BACKGROUND
Rodent studies suggest that luminal solutions alleviate the mucosal injury and prolong intestinal preservation but concerns exist that excessive volumes of luminal fluid may promote tissue edema. Differences in size, structure, and metabolism between rats and humans require studies in
Luminal solutions protect mucosal barrier during extended preservation.
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BACKGROUND
Mucosal barrier injury during intestinal preservation (IP) and transplantation favors life-threatening infections. Luminal delivery of solutions containing amino acids or polyethylene glycols (PEGs) may improve preservation results and reduce this injury. We tested if solutions containing
Intraluminal polyethylene glycol stabilizes tight junctions and improves intestinal preservation in the rat.
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Rapidly progressing mucosal breakdown limits the intestinal preservation time below 10 h. Recent studies indicate that intraluminal solutions containing polyethylene glycol (PEG) alleviate preservation injury of intestines stored in UW-Viaspan. We investigated whether a low-sodium PEG solution is
Treatment of rats with dexamethasone or thyroxine reverses zinc deficiency-induced intestinal damage.
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Structural and functional damage to the intestine and the potential beneficial effects of dexamethasone (Dex) and thyroxine (T4) were examined in zinc-deficient rats. Rats were assigned to zinc deficient (ZD), control (C) or pair-fed (PF ) groups and fed for 40 d a zinc deficient (1 mg/kg) diet (ZD
Chemical profiling of secondary metabolites of Eugenia uniflora and their antioxidant, anti-inflammatory, pain killing and anti-diabetic activities: A comprehensive approach.
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Transition from parenteral to enteral nutrition induces immediate diet-dependent gut histological and immunological responses in preterm neonates.
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Necrotizing enterocolitis (NEC) in preterm infants develops very rapidly from a mild intolerance to enteral feeding into intestinal mucosal hemorrhage, inflammation, and necrosis. We hypothesized that immediate feeding-induced gut responses precede later clinical NEC symptoms in preterm pigs.
Improved intestinal preservation using an intraluminal macromolecular solution: evidence from a rat model.
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BACKGROUND
Intestinal preservation injury consists of progressive submucosal edema, with fluid originating both from the lumen and the interstitium. Although vascular flushing aims to control electrolyte shifts in the tissue, the lumen is not addressed, and luminal water and electrolytes enter the
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