mannitol/necrotisch

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The protective effect of hyperosmotic mannitol in myocardial ischemia and necrosis.

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Morphologic and hemodynamic changes that occur following coronary occlusion are examined. The effectiveness of hyperosmotic mannitol in lessening the extent of myocardial damage is assessed and mechanisms for its action discussed. Forty and 60 min of coronary vascular occlusion followed by 15 and 45

Mannitol protects hair cells against tumor necrosis factor α-induced loss.

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OBJECTIVE Mannitol has otoprotective effects against tumor necrosis factor (TNF) α-induced auditory hair cell (HC) loss. BACKGROUND Mannitol has been demonstrated to possess cytoprotective effects in several organ systems. Its protective effect on postischemic hearing loss has also been shown.

Effects of hyperosmotic mannitol in reducing ischemic cell swelling and minimizing myocardial necrosis.

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Impaired metabolism interferes with the active extrusion of intracellular sodium and results in intracellular edema. In the brain and regionally in the kidney, elevation of extracellular osmolality is accompanied by a reduction of ischemic cell swelling and improvement of reflow of blood after

Ischemia and reperfusion in skin flaps: effects of mannitol and vitamin C in reducing necrosis area in a rat experimental model.

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OBJECTIVE The aim of the present study was to develop an experimental model of ischemia-reperfusion injury in rat skin flap and to verify the effect of mannitol and vitamin C on reducing necrosis area. METHODS A 6- x 3-cm groin skin flap was raised and submitted to 8 hours of ischemia by clamping

Prevention of acute tubular necrosis in cadaveric kidney transplantation by the combined use of mannitol and moderate hydration.

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Recent studies have indicated that maximal hydration of the transplant recipient can substantially reduce the incidence of acute tubular necrosis (ATN). However, this policy requires invasive hemodynamic monitoring, prolonged mechanical ventilation, and bears the risk of overhydration. In a

[Effect of mannitol on serum tumor necrosis factor-α and interleukin-6 levels and the mechanism of its organ-protective effect in rabbits early after severe burn injury].

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OBJECTIVE To investigate the protective effect of mannitol therapy on the vital organs and explore the underlying mechanisms in New Zealand rabbits with severe burn injury. METHODS Twelve New Zealand rabbits with severe burn injury (30% of TBSA) were randomized to receive fluid resuscitation with

Blood reflow after renal ischemia. Effects of hypertonic mannitol on reflow and tubular necrosis after transient ischemia in the rat.

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Effects of hyperosmotic mannitol in reducing ischemic cell swelling and minimizing myocardial necrosis. Discussion.

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Are there any evidence-based indications for the use of mannitol in acute tubular necrosis?

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[Mannitol and dextran of low molecular weight in the prevention of post blood transfusion tubular necrosis].

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RELATION OF ACUTE TUBULAR NECROSIS TO SHOCK AND THE EFFECT OF MANNITOL.

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Effects of hyperosomotic mannitol in reducing ischemic swelling and minimizing myocardial necrosis. Discussion.

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Effect of tumor necrosis factor-alpha on the permeability of bovine brain microvessel endothelial cell monolayers.

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The administration of chemotherapy to patients with tumors of the central nervous system is often blocked by the blood-brain barrier. Tumor necrosis factor-alpha (TNF-alpha) is a cytokine that promotes vascular permeability in addition to its pro-inflammatory effects. However, no direct evidence

The effect of mannitol on experimental cerebral ischemia, revisited.

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The effect of 20% mannitol on ischemic neuronal injury was examined in male Wistar rats (n = 80) that were randomly divided into forebrain and focal ischemia groups. The animals were further subdivided into control, treatment with mannitol before ischemia (1 g/kg of body weight, 12 min before

Intracoronary hyperosmotic mannitol during reperfusion does not affect infarct size in ischemic, reperfused porcine hearts.

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We investigated the effect of reperfusion with hyperosmotic mannitol on the infarct size in porcine hearts. The distal half of the left anterior descending coronary artery was occluded in each of 21 anesthetized pigs for 75 min and was reperfused for 2 h. During reperfusion mannitol (1075 mosmol/kg)

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