methyl nicotinate/inflammatie

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Establishing a minimal erythema concentration of methyl nicotinate for optimum evaluation of anti-inflammatories.

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Topical administration of chemicals such as methyl nicotinate that induce erythema have been employed to measure the effectiveness of formulations containing anti-inflammatory agents. Prior studies have utilized a single concentration of methyl nicotinate, between 36.5 and 100 mM, for all test

Objective assessment of topical corticosteroids and non-steroidal anti-inflammatory drugs in methyl-nicotinate-induced skin inflammation.

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The aim of this study was to compare the activities of the two main classes of topical anti-inflammatory drugs in methyl-nicotinate-induced skin inflammation, using a new methodology based on laser-Doppler velocimetry. Six topical non-steroidal anti-inflammatory drugs (NSAIDs) (bufexamac,

Feasibility of measuring the bioavailability of topical ibuprofen in commercial formulations using drug content in epidermis and a methyl nicotinate skin inflammation assay.

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A method has been developed which simultaneously compares the inhibition of an inflammation induced by a methyl nicotinate assay with the concentration of drug in the human epidermis determined in vitro following topical application of two 10% ibuprofen formulations. The bioavailability of drug from

Determination of the in vivo bioavailability of iontophoretically delivered diclofenac using a methyl nicotinate skin inflammation assay.

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OBJECTIVE In this study, we investigated the bioavailability of iontophoretically delivered diclofenac with the methylnicotinate (MN) test. The inhibition of an erythema provoked by MN is proportional to the bioavailability of diclofenac in the skin. It was our aim to use this procedure in the

Microcirculatory response of skin to benzoic acid and methyl nicotinate in patients with diabetes.

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OBJECTIVE In view of the relationship between microvascular pathology and organ complications in diabetes mellitus, the aim of the present study was to examine the microvascular response of upper arm skin to non-immunological contact irritants in 17 insulin-dependent diabetic patients and 11

Topical non-steroidal anti-inflammatory drugs inhibit non-immunologic immediate contact reactions.

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The effects of 3 topical applications of non-steroidal anti-inflammatory drugs (NSAIDs), diclofenac 1%, naproxene 10% and salicylic acid 5% in gel vehicles, on immediate contact reactions to 500 mM benzoic acid, 500 mM cinnamic aldehyde, 50 mM methyl nicotinate, all in pet., and 14.1 M (100%)

Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine.

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BACKGROUND Wu-Zhu-Yu, is an extract prepared from the small berry fruit of Evodia rutaecarpa and is reported to have anti-inflammatory and anti-nociceptic activity. Methyl nicotinate (MN) is known to induce the release of PGD(2) resulting in localized erythema within 30 min after topical application

Assessment of topical non-steroidal anti-inflammatory drugs.

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A new non-invasive technique for assessing the efficacy of topical non-steroidal anti-inflammatory drugs (NSAID) in man is proposed. The NSAID are initially applied to the skin under occlusion before inflammation is induced by a methyl nicotinate solution. The inflammatory response is quantified in

Processing and statistical analysis of laser Doppler data applied to the assessment of systemic anti-inflammatory drugs.

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Continuous laser Doppler measurements of methyl nicotinate-induced skin inflammation have been used to evaluate the activities of three oral non-steroidal anti-inflammatory drugs, indomethacin 50 mg (Indocid), tiaprofenic acid 100 mg (Surgam) and sodium acetylsalicylate 1 g (Catalgine). They were

Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.

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BACKGROUND The aim of this work was to evaluate the suitability of ethosomes as carriers for the topical application of triptolide in a rat model of erythema. OBJECTIVE We determined the optimal conditions for preparing ethosomes, and we measured their vesicle size by a laser particle-size analyzer

Ex vivo penetration analysis and anti-inflammatory efficacy of the association of ferulic acid and UV filters

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Background: Unprotected chronic exposure to ultraviolet (UV) radiation generates many harmful effects to human skin and sunscreens are essential to health, however, traditional products do not provide enough protection against cutaneous

Correlation between percutaneous penetration of methyl nicotinate and sensitive skin, using laser Doppler imaging.

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Cutaneous penetration of methyl nicotinate has been investigated in 20 women divided into reactors and non-reactors on the basis of response to 10% aqueous solution of lactic acid. The vasodilation induced was measured using a laser Doppler perfusion imager (LDPI) every 5 min for 1 h after

Formulation study and anti-inflammatory efficacy of topical semi-solids containing a nitro ester of flurbiprofen.

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A new nitro-oxybutylester of flurbiprofen (NO-FP) is a promising anti-inflammatory drug in the treatment of dermatological disorders, and the feasibility of its cutaneous administration was evaluated. Four different semi-solid formulations were evaluated in order to assess the influence of the

Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium).

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Extracts of Tanacetum parthenium (L.) Sch. Bip., a plant known under the common name "Feverfew", contains the sesquiterpene lactone parthenolide, a potent skin sensitizer. To eliminate the risk of skin sensitization from Feverfew, we developed a parthenolide-depleted extract of Feverfew

Ketoprofen 1-alkylazacycloalkan-2-one esters as dermal prodrugs: in vivo and in vitro evaluations.

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Six new 1-alkylazacycloalkan-2-one esters of ketoprofen (1-6) were synthesized and evaluated as potential dermal prodrugs of ketoprofen. Their lipophilicity by both experimental lipophilicity indices (log k') and calculated ClogP was also determined. In vitro experiments were carried out to evaluate

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