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Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil.

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Despite all the research done on the first Zika virus (ZIKV) epidemics, it was only after the Brazilian epidemic that the Congenital Zika Syndrome was described. This was made possible due to the large number of babies born with microcephaly in the Northeast region (NE) in a narrow time. We

Zika virus infection, associated microcephaly, and low yellow fever vaccination coverage in Brazil: is there any causal link?

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BACKGROUND Since the end of 2014, Zika virus (ZIKV) infection has been rapidly spreading in Brazil. METHODS To analyze the possible association of yellow fever vaccine with a protective effect against ZIKV-related microcephaly, the following spatial analyses were performed, using Brazilian

A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia.

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We describe the clinical and biochemical characteristics in three patients from two different families diagnosed with Congenital Disorder of Glycosylation type IIe owing to a defect in Conserved Oligomeric Golgi complex (COG)7; one of the eight subunits of the COG. The siblings and an unrelated

Zika Virus Infection in Pregnant Women and Microcephaly.

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From the discovery of the Zika virus (ZIKV) in 1947 in Uganda (Africa), until its arrival in South America, it was not known that it would affect human reproductive life so severely. Today, damage to the central nervous system is known to be multiple, and microcephaly is considered the tip of the

[Zika virus - ancient virus gets new life in a new ecosystem. Microcephaly and Guillain-Barre syndrome are possible consequences when there is no background herd immunity in the population].

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Zika virus is a mosquito-borne flavivirus transmitted by Aedes mosquitos. The virus was discovered in 1947 in the Zika forest in Uganda. Symptomatic disease is usually mild and is characterized by maculopapular rash, headache, fever, arthralgia and conjunctivitis. Fatalities are rare. There is

Pyriproxyfen does not cause microcephaly or malformations in a preclinical mammalian model

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Pyriproxyfen is used in Brazil to combat epidemics of Dengue Fever, Chikungunya Fever, and Zika virus. This study assessed the effects of pyriproxyfen on reproductive performance, embryo-fetal development, head measurements, and DNA integrity in a preclinical model. Thirty pregnant mice were divided

Primary microcephaly in two children born to mothers with complicated appendicitis or late appendectomy during pregnancy.

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BACKGROUND The possible association between maternal appendicitis/appendectomy during pregnancy and congenital abnormalities in the offspring was studied. METHODS Two cases with primary microcephaly were born to mothers who had complicated appendicitis owing to the delay of appendectomy resulting in

Fever in pregnancy and offspring head circumference.

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OBJECTIVE To examine whether maternal fever during pregnancy is associated with reduced head circumference and risk of microcephaly at birth. METHODS A prospective study of 86,980 live-born singletons within the Danish National Birth Cohort was carried out. Self-reported maternal fever exposure was

Zika fever.

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Zika fever is an arboviral systemic disease that has recently become a public health challenge of global concern after its spread through the Americas. This review highlights the current understanding on Zika virus epidemiology, its routes of transmission, clinical manifestations, diagnostic tests,

Zika virus and microcephaly in Southeast Asia: A cause for concern?

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Zika virus (ZIKV), a mosquito transmitted virus in the family Flaviviridae, genus Flavivirus, recently emerged to cause infections in more than 70 countries and territories around the world. While human infection is normally asymptomatic, it can also result in a mild febrile disease similar to

Bilateral middle cerebral artery thromboembolic occlusion. Could maternal hyperthermia be a detrimental factor?

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We describe a six-month-old girl with microcephaly, developmental delay, truncal hypotonia, left pyramidal signs, partial seizures and myoclonic spasms, born to a feverish mother. MRI showed bilateral vascular lesions in the territory of the middle cerebral arteries, prevalent in the right

Fetal and placental responses to artificially induced hyperthermia in rats.

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Pregnant rats were utilized to study the effect of maternal hyperthermia on fetal development. Eight groups of six to eight rats were exposed to ambient temperatures of 43-44 degrees C at various stages of pregnancy. All rats were killed on day 20 of gestation. Edema, microencephaly and

The individual and combined effects of X-irradiation and hyperthermia on early somite mouse embryos in culture.

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The effects of 1) X-irradiation and 2) hyperthermia at a temperature of 43 degrees C individually and in combination have been investigated using cultured 8-day mouse embryos. B6C3F1 embryos were exposed to 0.3-2.0 Gy of X-rays, 5-20 min of heating, or 5 min of heating and irradiation at 0.3, 0.6,

Delineation of a multiple congenital abnormality syndrome in the offspring of pregnant women affected with high fever-related disorders: a population-based study.

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Our previous study showed an association between high fever-related maternal diseases during the second and/or third gestational months and a higher risk of multiple congenital abnormalities (MCA) in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital

Microcephaly, malformation of brain development and intracranial calcification in sibs: pseudo-TORCH or a new syndrome.

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We report on five sibs affected by congenital microcephaly, growth retardation, sloping forehead, bitemporal grooving and micrognathia. Generalized tonic-clonic seizures started very early in life. Postnatal brain computerized tomography (CT) presented cortical band-like calcification, calcification

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