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neurodegenerative diseases/hypoxie
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Bladzijde 1 van 44 resultaten
Methods for the treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration
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TECHNICAL FIELD OF THE INVENTION
This invention relates to pharmaceutical compositions useful for treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration, and to methods for using the compositions.
BACKGROUND OF THE INVENTION
Neurotrophic factors exhibit a trophic effect
Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to methods for preconditioning and/or providing neuroprotection to the animal central nervous system against ischemia, neurodegeneration, trauma and metal poisoning, including associated cognitive, behavioral and
Pharmaceutical compositions containing triazolones and methods of treating neurodegenerative disease using triazolones
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The invention relates to the use of triazolones as pharmaceutical compositions, particularly pharmaceutical compositions with a neuroprotective activity, as well as new triazolones and processes for preparing them.
Triazolones are known from the prior art and are disclosed, for example, by published
Compositions and methods for treating cancer and neurodegenerative diseases
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FIELD OF THE INVENTION
The present invention relates to compositions and methods for regulating death-associated protein kinase (DAPk) activity. The compositions and methods of the present invention are useful for treating or ameliorating cancer as well as pathologies associated with neuronal cell
Sublingual and buccal administration of selegiline for treating certain selegiline-responsive diseases and conditions
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FIELD OF THE INVENTION
The present invention pertains to improved methods for using selegiline in therapeutic applications. In particular, the invention is directed to improved methods for treating certain selegiline-responsive diseases and conditions by administering selegiline either buccally or
Oligonucleotides which inhibit p53 induction in response to cellular stress
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FIELD OF THE INVENTION
The present invention relates to modulating the activity of p53 tumor suppressor protein by affecting p53 translational regulation and its use for minimizing the negative effects of cellular stresses. More specifically, the invention relates to novel oligonucleotides which
Use of pyruvate to prevent neuronal degeneration associated with ischemia
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BACKGROUND OF THE INVENTION
The invention is in the fields of neurology and pharmacology and relates to protecting the brain and central nervous system against damage due to ischemia and other neurological disorders in which energy-providing substrates (oxygen and glucose) are reduced or energy
N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
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FIELD OF THE INVENTION
This invention is in the field of medicinal chemistry. In particular, this invention relates to N,N'-disubstituted guanidine analogues, and to compounds and pharmaceutical composition comprising the same, which possess neuroprotective capability. This invention further relates
N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
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BACKGROUND OF THE INVENTION
This invention relates to N,N'-disubstituted guanidine analogues, and to compounds and pharmaceutical compositions comprising the same, which possess neuroprotective capability. This invention further relates to methods for treating any disease of the nervous system in
N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
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FIELD OF THE INVENTION
This invention is in the field of medicinal chemistry. In particular, this invention relates to N,N'-disubstituted guanidine analogues, and to compounds and pharmaceutical composition comprising the same, which possess neuroprotective capability. This invention further relates
Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists
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FIELD OF THE INVENTION
This invention relates to tri- and tetra-substituted guanidines, and to pharmaceutical compositions comprising the same, which possess neuroprotective capability. This invention further relates to methods involving the use of these compounds as excitatory amino acid
Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
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FIELD OF THE INVENTION
This invention relates to tri- and tetra-substituted guanidines, and to pharmaceutical compositions comprising the same, which possess neuroprotective capability. This invention further relates to methods involving the use of these compounds as excitatory amino acid
Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
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FIELD OF THE INVENTION
This invention relates to tri- and tetra-substituted guanidines, and to pharmaceutical compositions comprising the same, which possess neuroprotective capability. This invention further relates to methods involving the use of these compounds as excitatory amino acid
Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
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FIELD OF THE INVENTION
This invention relates to tri- and tetra-substituted guanidines, and to pharmaceutical compositions comprising the same, which possess neuroprotective capability. This invention further relates to methods involving the use of these compounds as excitatory amino acid
Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
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FIELD OF THE INVENTION
This invention relates to tri- and tetra-substituted guanidines, and to pharmaceutical compositions comprising the same, which possess neuroprotective capability. This invention further relates to methods involving the use of these compounds as excitatory amino acid
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