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neurodegenerative diseases/tyrosine
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Bladzijde 1 van 23 resultaten
Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases
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Throughout this application various patent and nonpatent publications are referenced, full citations of which are provided. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to
Bsk receptor-like tyrosine kinase
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FIELD OF THE INVENTION
This invention is in the field of the neurotrophic receptors and their ligands. More specifically this invention relates to the receptor-like tyrosine kinase Bsk and its corresponding ligand and to therapeutic and diagnostic applications which employ the Bsk receptor or
Treating neural disease with tyrosine kinase inhibitors
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BACKGROUND
Neurodegenerative diseases include genetic and sporadic disorders associated with progressive nervous system dysfunction. It has been estimated that one of four Americans will develop a neurodegenerative condition in their lifetimes. Generally, however, the underlying mechanisms causing
Treating neural disease with tyrosine kinase inhibitors
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BACKGROUND
Neurodegenerative diseases include genetic and sporadic disorders associated with progressive nervous system dysfunction. It has been estimated that one of four Americans will develop a neurodegenerative condition in their lifetimes. Generally, however, the underlying mechanisms causing
Protein tyrosine phosphatase inhibitors and methods of use thereof
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FIELD OF THE INVENTION
This invention relates to the field of protein tyrosine phosphatase inhibition.
BACKGROUND OF THE INVENTION
This invention relates to a novel class of phosphonic acid derivatives that are inhibitors of PTP-1B.
Reversible protein tyrosine phosphorylation, coordinated by the
Protein tyrosine phosphatase inhibitors and methods of use thereof
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FIELD OF THE INVENTION
This invention relates to the field of protein tyrosine phosphatase inhibition.
BACKGROUND OF THE INVENTION
This invention relates to a novel class of phosphonic acid derivatives that are inhibitors of PTP-1B.
Reversible protein tyrosine phosphorylation, coordinated by the
Peptides for use in the topical treatment of retinal neurodegenerative diseases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role
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The present invention relates to the field of medical approaches for ocular diseases that may lead to partial or total blindness. The invention provides useful tools to be applied topically into the eyes, including peptides and analogs of these peptides.
BACKGROUND ART
Retinal neurodegenerative
Trk tyrosine kinase receptor is the physiological receptor for nerve growth factor
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FIELD OF THE INVENTION
The present invention relates to a complex comprising the neurotrophic factors: nerve growth factor (NGF) and trk-proto-oncogene receptor protein. The present invention also relates to methods for detecting the presence of NGF ligand, and trk-proto-oncogene receptor
TRK tyrosine kinase receptor is the physiological receptor for nerve growth factor
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FIELD OF THE INVENTION
The present invention relates to a complex comprising the neurotrophic factors: nerve growth factor (NGF) and trk-proto-oncogene receptor protein. The present invention also relates to methods for detecting the presence of NGF ligand, and trk-proto-oncogene receptor
Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase
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FIELD OF THE INVENTION
The invention described herein relates to methods of preventing or treating disorders in patients suffering from the effects of neuronal degeneration. The invention is based in part on the discovery that activation of the c-ret receptor is necessary for neuronal cell
Vector system
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The present invention relates to a vector system. In particular, the present invention relates to a lentiviral vector system for the treatment of Parkinson's disease.
BACKGROUND
Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of the
Substituted carboxylic acids
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to substituted carboxylic acids and more specifically to such compounds that are useful in the treatment of diabetes. More specifically, it relates to such compounds that are capable of inhibiting Protein tyrosine
Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
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The present invention relates to novel compounds that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety
Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors
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The present invention relates to novel compounds that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety
Kinase inhibitors
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The present invention relates to novel compounds that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety
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