phosphofructokinase/vermoeidheid

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Glucose-induced exertional fatigue in muscle phosphofructokinase deficiency.

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BACKGROUND The exercise capacity of patients with muscle phosphofructokinase deficiency is low and fluctuates from day to day. The basis of this variable exercise tolerance is unknown, but our patients with this disorder report that fatigue of active muscles is more rapid after a high-carbohydrate

The effect of fatigue on the binding of glycolytic enzymes in the isolated gastrocnemius of Rana pipiens.

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Fatigue of isolated gastrocnemius muscles from R. pipiens leads to a marked increase in the proportion of phosphofructokinase bound to the particulate fraction and a decrease in the binding of lactate dehydrogenase, pyruvate kinase, creatine phosphokinase and glyceraldehyde-3-phosphate

Recovery of muscle from tetrodotoxin-induced disuse and the influence of daily exercise. 2. Muscle enzymes and fatigue characteristics.

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The fatigue characteristics and the activities of oxidative and glycolytic enzymes were determined in tetrodotoxin (TTX)-induced disuse muscles and in muscles of animals recovering from TTX-induced disuse (TTX-rec). In addition, the effects of additional daily exercise (grid-climbing and swimming)

Contractile and biochemical properties of diaphragm: effects of exercise training and fatigue.

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The effect of high-intensity trained (6 X 4.5 min at 40 m/min, 15% grade, 2.5-min rest between bouts, 5 days/wk, for 6 wk) on contractile, biochemical, and fatigue properties of the rat diaphragm were examined. The exercise program produced significant elevations in the mitochondrial marker enzyme

High oxidative capacity and type IIx fibre content in springbok and fallow deer skeletal muscle suggest fast sprinters with a resistance to fatigue.

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Some wild antelopes are fast sprinters and more resistant to fatigue than others. This study therefore investigated two wild antelope species to better understand their reported performance capability. Muscle samples collected post mortem from the vastus lateralis and longissimus lumborum of fallow

Effect of temperature on muscle energy metabolism and endurance during successive isometric contractions, sustained to fatigue, of the quadriceps muscle in man.

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1. The effects of altered tissue temperature on muscle metabolism during successive isometric contractions, sustained to fatigue, have been studied in the quadriceps muscle of man by combining biochemical analyses of metabolites in needle biopsy samples with measurements of endurance time with a

Muscle phosphofructokinase deficiency in two generations.

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Phosphofructokinase (PFK) is the key regulatory enzyme of glycolysis. Patients lacking the muscular isoform of PFK typically present with myopathy and compensated hemolysis (glycogenosis type VII or Tarui's disease). Since 1965 about 30 cases of muscular PFK deficiency have been reported. In most

Effects of citrulline supplementation on fatigue and exercise performance in mice.

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During high-intensity exercise, the concentration of ammonia is augmented in skeletal muscle. Ammonia activates phosphofructokinase and prevents oxidation of pyruvate to acetyl CoA, thus leading to exhaustion. Citrulline is an amino acid component of the urea cycle in the liver, along with ornithine

Paradoxically enhanced glucose production during exercise in humans with blocked glycolysis caused by muscle phosphofructokinase deficiency.

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Muscle phosphofructokinase deficiency (PFKD) is characterized by exercise intolerance due to the enzymatic block in muscle glycolysis. Glucose infusion increases exertional fatigue in these patients, probably by decreasing the availability of free fatty acids (FFA) and ketones, which play a crucial

Fatigue and phosphocreatine depletion during carbon dioxide-induced acidosis in rat muscle.

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Isolated extensor digitorum longus muscles from rat were exposed to atmospheres of 30% CO2 (high-CO2 muscles) or 6.5% CO2 (control muscles) in O2 for 95 min. Muscle contraction characteristics were studied before and after the incubation. Tetanic tension decreased in high-CO2 muscles to 55% of

Muscle fatigue and lactic acid accumulation.

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Lactic acid is formed and accumulated in the muscle under conditions of high energy demand, rapid fluctuations of the energy requirement and insufficient supply of O2. During intense exercise sustained to fatigue muscle pH decreases to about 6.4-6.6. Force generation does not appear to be limited by

Different modes of activating phosphofructokinase, a key regulatory enzyme of glycolysis, in working vertebrate muscle.

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Glycolytic flux in white muscle can be increased several-hundredfold by exercise. Phosphofructokinase (PFK; EC 2.7.1.11) is a key regulatory enzyme of glycolysis, but how its activity in muscle is controlled is not fully understood. In order not to neglect integrative aspects of metabolic

The effect of β-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue.

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The study investigated the influence of β-Alanine supplementation during a high-intensity interval training (HIIT) program on repeated sprint ability (RSA) performance. This study was randomized, double-blinded and placebo-controlled. Eighteen men performed an incremental running test until

Histochemical and biochemical correlates of ventilatory muscle fatigue in emphysematous hamsters.

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Histochemical and biochemical characteristics of the ventilatory muscles were evaluated in control and elastase-induced emphysematous hamsters. The emphysematous group was divided into sedentary and endurance-trained groups. Endurance training consisted of treadmill running, 1 h a day, 7 d a week.

Responses of fatigable and fatigue-resistant fibres of rabbit muscle to low-frequency stimulation.

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This study investigates early adaptive responses of fast-twitch muscle to increased contractile activity by low-frequency stimulation. Changes in metabolite levels and activities of regulatory enzymes of carbohydrate metabolism were investigated in rabbit tibialis anterior muscle after 24 h of

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