primary immunodeficiency diseases/protease

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A Multi-Center Study Evaluating Clinical Course in Patients With COVID19 and Its Relationship to Cytokine Storm

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Study Rationale Over 100 patients were hospitalized at Hadassah in the recent 2 months with the diagnosis of COVID19. We would like to summarize the clinical outcomes and their correlation to a cytokine storm at Hadassah and additional hospitals and additional hospitals in Israel. COVID-19, the name

Contributing Factors for Poor HIV Treatment Response in Children With TB/HIV Coinfection

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In a previous study, the study team found that first-line anti-TB therapy had minimal effect on EFV pharmacokinetics (PK) at the population level, but children with TB/HIV coinfection on anti-TB therapy had a trend towards worse virologic outcome compared to those with only HIV infection. Due to the

Effect on HIV Medications on EPC Cells

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Metabolic and endocrine perturbations including insulin resistance, diabetes, and dyslipidemia have been of significant concern in human immunodeficiency virus (HIV)-infected individuals. HIV-infected individuals may be at risk of accelerated atherosclerotic cardiovascular disease (CVD) and

Clinical Trial to Evaluate the Efficacy of a Dyslipidemic Therapy in Mexican Population

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General objectives: Evaluate the therapeutic efficacy in Mexican adults with dyslipidemia through the oral route use of L-carnitine + atorvastatin in comparison with the use of Atorvastatin, after six months of treatment. Evaluate the safety of the medicines under study. Hypothesis: The combined use

Isotretinoin In Preventing Recurrences In Chronic Recurrent Dermatophytosis

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Over the last couple of years, the major concern in dermatophytic infections has been the occurrence of recurrent infections. This, in spite of the patients being treated with gold standard drugs, namely, terbinafine, griseofulvin, and even azoles like itraconazole, in adequate doses. The world is

Individualized Antiretroviral Therapy

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I) General Objectives To establish the overall impact of pharmacogenomic (PG) analysis and therapeutic drug monitoring (TDM) for the selection of the proper dose of efavirenz or atazanavir in patients with an HIV infection who have not received prior antiretroviral treatment. II) Specific objectives

Effects of Ledipasvir/Sofosbuvir on the Pharmacokinetics and Renal Safety of Tenofovir Alafenamide (TAF)

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Effectiveness of Raltegravir-Based Antiretroviral Therapy in HIV-HCV Coinfected Liver Transplant Recipients

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With the advent of combined antiretroviral therapy (cART), patients infected with human immunodeficiency virus type 1 (HIV) are now living longer and dying of illnesses other than acquired immunodeficiency syndrome. Although outcome of liver transplantation (LT) in HIV and hepatitis C virus

Protease Inhibitor vs. Raltegravir-based ART and Inflammation in HIV Infection

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Simplification From Tenofovir Plus Lamivudine or Emtricitabine Plus Ritonavir-Boosted-Protease Inhibitor to Ritonavir-Boosted-Atazanavir Plus Lamivudine in Virologically-Suppressed-HIVInfected Adults With Osteopenia

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Effects of Sofosbuvir/Ledipasvir Treatment on the Pharmacokinetics and Renal Safety of Tenofovir

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Bone Mineral Density in Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Adult Subjects Switching From a Tenofovir Regimen to a Dolutegravir Plus Rilpivirine Regimen

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Pilot Study of Oral Probiotic Bacteria Supplementation to Reduce Chronic Immune Activation in HIV-infected Malian Women

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Excessive immune system stimulation, activation, and associated inflammation play a central role in the pathogenesis of HIV disease. The level of T-cell and monocyte activation predicts the rate of HIV disease progression to AIDS, the slope of CD4+ T-cell loss, and mortality [Liu 1997, Liu 1998,

Regimen Switch to Dolutegravir + Rilpivirine From Current Antiretroviral Regimen in Human Immunodeficiency Virus Type 1 Infected and Virologically Suppressed Adults (SWORD-1)

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Regimen Switch to Dolutegravir + Rilpivirine From Current Antiretroviral Regimen in Human Immunodeficiency Virus Type 1 Infected and Virologically Suppressed Adults (SWORD-2)

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