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primary ovarian insufficiency/misselijkheid
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Health and reproductive experiences of women with an FMR1 premutation with and without fragile X premature ovarian insufficiency.
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Recently, research has indicated an increased risk for greater medical and emotional comorbidity and physical health symptoms among women with an FMR1 expansion. However, these studies have generally been limited in their ability to model multiple risk factors associated with these symptoms by small
Low-dose intravenous cyclophosphamide in systemic sclerosis: a preliminary safety study.
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Both oral and intravenous high-dose cyclophosphamide (CYC) regimens are associated with serious side effects when used for the treatment of systemic sclerosis (SSc). The aim of the present trial was to test the safety of low-dose intravenous CYC in patients with SSc. Eight SSc patients, in whom CYC
Addison's Disease in Evolution: An Illustrative Case and Literature Review.
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OBJECTIVE
To present a case of symptomatic autoimmune adrenal insufficiency with initially normal serum cortisol and to caution about limitations of the current diagnostic algorithm for adrenal insufficiency, which does not reflect the pathophysiology of early disease.
METHODS
We describe the
Sustained remission of metastatic adrenal carcinoma during long-term administration of low-dose mitotane.
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We present our experience with two female patients suffering from metastatic, recurrent adrenocortical carcinomas, to whom o,p'-DDD (mitotane) was administered for unusually long duration. The first patient received mitotane as monotherapy after relapse (in doses ranging from 3 to 6 g/day initially
Goserelin versus cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy in premenopausal patients with node-positive breast cancer: The Zoladex Early Breast Cancer Research Association Study.
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OBJECTIVE
Current adjuvant therapies have improved survival for premenopausal patients with breast cancer but may have short-term toxic effects and long-term effects associated with premature menopause.
METHODS
The Zoladex Early Breast Cancer Research Association study assessed the efficacy and
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