prostatitis/glutathione

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Oxidative stress in leucocytospermic prostatitis patients: preliminary results.

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The aim of this study was to contribute to the knowledge concerning pathogenesis of inflammatory chronic prostatitis by revealing possible shifts in the balance of markers of oxidative stress and anti-oxidative activity in case of leucocytospermic prostatitis. We also attempted to identify possible

Immunohistochemical expression of pi class glutathione S-transferase in the basal cell layer of benign prostate tissue following chronic treatment with finasteride.

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BACKGROUND Glutathione S-transferases (GST) may prevent carcinogenesis through inactivation of reactive electrophiles by conjugation to reduced glutathione. Treatment directed at the induction or preservation of GST-pi expression in normal epithelium could have a profound impact on the prevention of

The effect of pirfenidone on rat chronic prostatitis/chronic pelvic pain syndrome and its mechanisms

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Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an intractable problem of the urogenital system. The aetiopathogenesis and effective treatments for CP/CPPS are needed to be untangled. Pirfenidone is a molecule

The Potential Protective Effect of Orange Peel and Selenium against 17β-Estradiol-Induced Chronic Non-Bacterial Prostatitis in Rats.

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Prostate Cancer (PCa) is defined as a major health problem facing the male population.We aimed to investigate the protective effects of Orange Peel Extract (OPE) and/or selenium (Se) on chronic non-bacterial prostatitis in a rat

Anti-inflammatory and antioxidant activity of thymoquinone in a rat model of acute bacterial prostatitis.

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Prostatitis plays a major role in morbidity and mortality related to prostate diseases. The aim of this study was to detect whether thymoquinone (TQ) could ameliorate oxidative damage and the proliferative response induced by Escherichia coli (E. coli) in rats. A total of 42 adult male Wistar rats

Oxidative stress-related parameters in prostate of rats with experimental autoimmune prostatitis.

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BACKGROUND Oxidative stress in tissues can be provoked by an augmented metabolic rate, which may sometimes be combined with a decrease in the antioxidant capacity. METHODS In this study we examined the primary enzymatic defense mechanisms against the damage caused by reactive oxygen species (ROS):

Increased oxidative stress and oxidative damage associated with chronic bacterial prostatitis.

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OBJECTIVE To investigate whether chronic bacterial prostatitis might increase oxidative stress and oxidative damage in chronic bacterial prostatitis patients (CBPP), and to explore its possible mechanism. METHODS Enrolled in a case-control study were 70 randomly sampled CBPP and 70 randomly sampled

Are prostatitis symptoms associated with an isoprostane-mediated vicious circle?

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Prostatitis is a disease that seriously affects the quality of patients' life. In the majority of cases, chronic prostatitis (chronic pelvic pain syndrome--CPPS) has an unclear pathogenesis. Anti-inflammatory and anti-infectious treatments have remained controversial. According to the latest

Preventive effects of oligomerized polyphenol on estradiol-induced prostatitis in rats.

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OBJECTIVE Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS, NIH category III) accounts for 90-95% of prostatitis cases. However, standard treatment has not yet been established. It is known that polyphenols have an inhibitory effect on inflammation by their antioxidative capacity, and

Anti-inflammatory and antioxidant effect of modified Bazhengsan in a rat model of chronic bacterial prostatitis.

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BACKGROUND Bazhengsan is a commonly used traditional Chinese prescription for the treatment of the urogenital system diseases for thousands of years, which decoction was first described in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy in Song Dynasty. OBJECTIVE In this study, the

Antioxidative and anti-inflammatory effect of thymoquinone in an acute Pseudomonas prostatitis rat model.

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BACKGROUND The aim of this study is to investigate the potential antioxidant and anti-inflammatory effects of thymoquinone (TQ) to improve acute bacterial prostatitis (ABP) induced by Pseudomonas aeruginosa. METHODS A total of 42 male Wistar albino rats were divided into 7 groups as follows:

New therapy with XLQ® to suppress chronic prostatitis through its anti-inflammatory and antioxidative activities.

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Chronic prostatitis is a common urological disease. The etiology of this disease and effective therapy for its treatment are yet to be elucidated. We investigated the functions of XLQ^® in chronic nonbacterial prostatitis using a complete Freund's adjuvant-induced rat model. Prostates and

MicroRNA-155 deficiency attenuates inflammation and oxidative stress in experimental autoimmune prostatitis in a TLR4-dependent manner

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To explore the mechanism of microRNA-155 (miR-155) deficiency, protecting against experimental autoimmune prostatitis (EAP) in a toll-like receptor 4 (TLR4)-dependent manner. After wild-type (WT) and miR-155^-/- mice were injected with complete Freund's adjuvant and prostate antigen to

[Antioxidant power and cellular damage in prostate cancer].

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OBJECTIVE To determine and compare the antioxidant power, cellular damage by lipidic peroxidation, and membrane damage in normal patients and patients with prostate cancer, so determining the antitumoral capacity. METHODS The study population included 19 patients with elevated total PSA, greater

Pathological lesions and global DNA methylation in rat prostate under streptozotocin-induced diabetes and melatonin supplementation.

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Chronic hyperglycemia increases production of reactive oxygen species, which favors carcinogenesis. The association between diabetes and prostate cancer is controversial. Melatonin has antioxidant, anti-inflammatory, and antiproliferative properties. We investigated whether low doses of melatonin

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