Retinopathy of Prematurity

to investigate side effects of eye drops used

Drug used in the examination of premature infants.

Efficacy of Mydriatic Drops in Premature Infants

Efficiency and Safety of Phenylephrine and Tropicamide Used in Premature Retinopathy

will be measured with a ruler after 60 minutes instillation of mydriatic

Atilla Alpay

Asociate Pofessor Atilla Alpay

Bulent Ecevit University

Infants will receive 15 minute trials of noninvasive neurally adjusted ventilatory assist (NIV NAVA) and nasal intermittent positive pressure ventilation (NIPPV) in random order with the first 10 minutes after changing to be considered a washout period and the last 5 minutes used for data collection. This group will receive NIV NAVA then NIPPV.

Infants will receive 15 minute trials of noninvasive neurally adjusted ventilatory assist (NIV NAVA) and nasal intermittent positive pressure ventilation (NIPPV) in random order with the first 10 minutes after changing to be considered a washout period and the last 5 minutes used for data collection. This group will receive NIPPV then NIV NAVA.

Respiratory Distress Syndrome, Newborn

Bronchopulmonary Dysplasia

Neurally adjusted ventilatory assist (NAVA) is a mode of ventilation that uses a functional naso/orogastric tube with embedded electrodes which detect diaphragmatic contractions (called the Edi signal). NAVA uses this Edi signal to synchronize ventilator support to the patient's own respiratory efforts and to support these efforts as needed.

Noninvasive neurally adjusted ventilatory assist (NIV NAVA)

Nasal intermittent positive pressure ventilation (NIPPV) or noninvasive pressure control ventilation (NIV PC) is a mode of ventilation delivering unsynchronized puffs of air or "breaths" to a baby through nasal cannulae.

Nasal intermittent positive pressure ventilation (NIPPV)

Arkansas Children's Hospital

Work of Breathing During Non-invasive Ventilation in Premature Neonates

Prospective Crossover Comparison of Work of Breathing During Non-invasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) in Premature Neonates

The primary outcome of interest is phase angle (θ). Phase angle is reflective of work of breathing. Respiratory inductance plethysmography (RIP) signals will be analyzed as sine waves of the same frequency for the phase angle as follows: θ = (δt/P) x 360 degrees, where δt represents the time shift between the two sine waves and P is the wave period or cycle time.

Tidal volume (arbitrary units, AU) measured by respiratory inductance plethysmography

Minute ventilation (AU/min) measured by respiratory inductance plethysmography

Oxygen saturation (%) measured by pulse oximetry

Total number of asynchrony events divided by sum of ventilator cycles and ineffective efforts expressed as a percentage

retinopathy of prematurity/braken

Efficacy of Mydriatic Drops in Premature Infants

Work of Breathing During Non-invasive Ventilation in Premature Neonates

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