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Arthritis in Assiut University Children Hospital

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Arthritis is defined as inflammation of the joint, Patients have symptoms of joint pain, stiffness, swelling, redness, warmth and decreased range of motion of the affected joints. Arthritis may be caused by transient synovitis, juvenile idiopathic arthritis ( JIA), reactive arthritis, viral

Denosumab and Male Infertility: a RCT

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INTRODUCTION Infertility is a serious problem estimated to affect 7-26% of all couples globally (1;2). Approximately 9% of all newborns were conceived by assisted reproductive techniques in 2013 in Denmark (Danish Fertility Society). Impaired semen quality is the causal or contributing factor in

Additive Benefit of the Urine LAM Test to Current TB Diagnostics in HIV Positive Adults in Panama City, Panama

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The gold standard for TB diagnosis, mycobacterial culture, is limited by a slow turnaround time, the need for skilled technicians and biosafety level 3 facilities. Another diagnostic test, Xpert MTB/RIF, produces same-day results, boasts a specificity of 98%, but is limited in the HIV population by

THOR - Tübingen Choroideremia Gene Therapy Trial

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Study name: THOR - Tübingen Choroideremia gene therapy trial open label Phase 2 clinical trial using an adeno-associated viral vector (AAV2) encoding Rab-escort protein 1 (REP1) Phase: Phase II Indication: Adult males with a clinical phenotype of choroideremia and a confirmed molecular diagnosis of

Intravenous Immunoglobulin Therapy for Small Fiber Neuropathy

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Small nerve fiber neuropathy (SFN) is a disorder of thinly myelinated and unmyelinated nerve fibers recently recognized as a distinct clinical syndrome, with a minimum incidence of 12 per 100.000 and a minimum prevalence of 53 per 100.000. The clinical picture is typically dominated by neuropathic

Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis

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CBD and sarcoidosis are granulomatous lung diseases that are caused by an abnormal immune response. While CBD is known to develop from exposure to the industrial product beryllium, the cause of sarcoidosis remains undetermined. CBD occurs in 2 to 16% of people exposed to beryllium and varies in

Trial of Adalimumab in Progressive Sarcoidosis

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This study consists of 11 visits (including screening). Screening Procedures: A chest radiograph (PA and lateral) must be obtained within 3 months prior to the first study injection. It must indicate that subject is free of tuberculosis (TB). The chest radiograph will also be used to confirm the

Hematopoietic Stem Cell Support in Patients With Refractory Sarcoidosis

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Method of Harvesting Stem Cells Based on the experience of the pilot studies, the current protocol will mobilize stem cells with granulocyte-colony stimulating factor (G-CSF) and collect stem cells by apheresis, with subsequent bone marrow harvest performed only if needed to supplement the

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