The placebo will be dispensed to equal the volume of 1 tablet of Probiotic PS128, which is taken orally in 2 divided doses, 12 hours apart during the study period of 2 months for Tic disorders.

The Probiotic group in tic disorder will take Probiotic-Lactobacillus plantarum PS128, which contain 300mg (3x10^10 CFU) Lactobacillus plantarum PS128 and 100mg of Microcrystalline Cellulose in each tablet. It will be taken orally in 2 divided doses, 12 hours apart during the study period of 2 months for Tic disorders.

The placebo will be dispensed to equal the volume of 1 tablet of Probiotic PS128, which is taken orally in 2 divided doses, 12 hours apart during the study period of 4 months for Rett syndrome

The Probiotic group will take Probiotic-Lactobacillus plantarum PS128, which contain 300mg (3x10^10 CFU) Lactobacillus plantarum PS128 and 100mg of Microcrystalline Cellulose in each tablet. It will be taken orally in 2 divided doses, 12 hours apart during the study period of 4 months for Rett Syndrome.

Rett Syndrome

Tourette Syndrome

Tic Disorders

Probiotic supplement of Lactobacillus plantarum PS128 , 1 tablet , twice a day , 12 hrs apart, lasting 2 months for Tic disorders and 4 months for Rett syndrome

Probiotic-Lactobacillus plantarum PS128

placebo , 1 tablet , twice a day , 12 hrs apart, lasting 2 months for Tic disorders and 4 months for Rett syndrome

Placebo

National Taiwan University Children Hospital

The Role of Probiotics PS128 in Movement Disorders

National Taiwan University Hospital

Randomized double blind placebo-controlled

internet-delivered Comprehensive Behavioral Intervention for Tics (iCBIT) consisting of psychoeducation, habit reversal training (HRT), function-based assessment and intervention, and relaxation training

internet-delivered psychoeducation and relaxation training.

Tics

(i)Comprehensive Behavioral Intervention for Tics

internet-delivered psychoeducation and relaxation training

Psychiatric Clinic of the Ludwig-Maximilians-University

Psychotherapist practice

RWTH Aachen, Department of Psychiatry, Psychotherapy and Psychosomatics

University of Dresden, Dep. of Child and Adolescent Psychiatry

University Medical Center Schleswig-Holstein, UK-SH Campus Lübeck, Department of Neurology

Trial to Demonstrate the Efficacy and Safety of Internet-delivered Behavioral Treatment for Adults With Tic Disorders

Randomized Observer Blind Clinical Trial to Demonstrate the Efficacy and Safety of Internet-delivered Behavioral Treatment for Adults With Tic Disorders

Kirsten Mueller-Vahl

Professor, MD

Hannover Medical School

Comprehensive Behavioral Intervention for Tics

Click here for the Tourette Syndrome Association, Inc. website

tic disorders/dopamine

The Role of Probiotics PS128 in Movement Disorders

Trial to Demonstrate the Efficacy and Safety of Internet-delivered Behavioral Treatment for Adults With Tic Disorders

Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children

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