Sodium propionate will be administered with a daily intake of 2 x 500 mg in form of capsules for 12 weeks.

Endstage Renal Disease

Sodium propionate is a non-toxic food additive, confirmed and licensed by the European Food Safety Authority (EFSA) sodium propionate E281. We are planning the oral application of 500 mg SP 2x per day. This dose is about 0.014 mg/kg of the body weight. Therefore, no risk of toxicity is expected in the patients.

Sodium Propionate

Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis

Effects of Short-chain Fatty Acids, Here Sodium Propionate, a Metabolism Product of the Human Gut-microbiome, on Inflammatory and Metabolic Parameters in Patients on Maintenance Hemodialysis - a Pilot Study

endotoxin /lipopolysaccharide levels, high sensitivity C-reactive protein (hs-CRP), fibrinogen, interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), IL-10, IL-2, INFγ, TGFβ, IL-4, IL-1β, IL-17a and white blood cell count.

glutathione peroxidase, malone dialdehyde

Determination of Homa Index (Homeostasis Model Assessment) by measurement fasting blood sugar and insulin level as well as hemoglobin HbA1c. IR appears to be as associated of metabolic disorders including lipid abnormalities, atherosclerotic cardiovascular disease and accelerated muscle protein degradation (Wang et al. 2006). IL is induced in particular by systemic inflammation.

Triglycerides, total cholesterol, high and low density cholesterol

Leptin, resistin, adiponectin and glucagon-like peptide -1.

p-cresyl sulfate, indoxyl sulfate and trimethylamine -N-oxide

Dr Biagio Di Iorio

Dr, Chief Nephrology Division

Azienda Sanitaria ASL Avellino 2

Isocaloric isonitrogenous placebo for 4 months (7g, twice daily)

BCAA mixture for 4 months (7g, twice daily)

Undernutrition

Branched chain amino acids (BCAA)

Placebo

Hospital of Sion

Cécil clinic

Lausanne University Hospital

Geneva University Hospital

Champel clinic

Microbiota and Protein-energy Wasting (MIDIWA)

Do Branched Chain Amino Acids Counteract Protein Energy Wasting Through Gut Microbiota Changes in Hemodialysis Patients ?

Genton Graf Laurence

Associate Physician at Clinical Nutrition Unit

University Hospital, Geneva

6 g of Winclove-849 containing Bifidobacterium bifidum W23, Bifidobacterium lactis W52, Lactobacillus acidophilus W37, Lactobacillus brevis W63, Lactobacillus casei W56, Lactobacillus salivarius W24, Lactococcus lactis W19, Lactococcus lactis W58 at a concentration of 2.5 x 109 cfu/g

similar looking and tasting placebo without bacteria

End-stage Renal Disease

Probiotic

Department of Internal Medicine, Medical University of Graz

Modulation of Gut Microbiota in End-stage Renal Disease

Modulation of Gut Microbiota in End-stage Renal Disease: A Pilot Study

Medical University of Graz

5 patients with polycystic kidney disease with eGFR > 60 ml/min.

5 patients with polycystic kidney disease with eGFR between 15-60 ml/min.

5 patients with polycystic kidney disease with eGFR <15 ml/min.

Serum and urine will be saved for metabolite analysis; stool will be used to extract bacterial DNA for sequencing.

Polycystic Kidney Disease

Icahn School of Medicine at Mount Sinai

Evaluation of Gut Bacteria in Patients With Polycystic Kidney Disease

Gut Microbiota of Renal Patients

The diversity of gut bacterial population and its correlation with the renal function, bacterial DNA extract will be sequenced using MiSeq. Data will be analyzed using QiiMe program.

To evaluate the uremic metabolites and its association with specific bacterial phylum identified by bacterial DNA sequencing

To evaluate the correlation of uremic metabolites in urine and its correlation with renal function by analyzing non-targeted metabolite profiling platform.

The correlation of Vit D level with gut bacterial population, and its effects on urine and serum metabolites.

uremia/obesitas

Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis

Microbiota and Protein-energy Wasting (MIDIWA)

Modulation of Gut Microbiota in End-stage Renal Disease

Evaluation of Gut Bacteria in Patients With Polycystic Kidney Disease

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