Transcripts of genes related to calcification (osteopontin, osteokalcin, RunX2), inflammation (TNFa, IL6) and atherosclerosis (ACE/ACE2, VCAM-1, ICAM-1) processes will be assessed.

End Stage Renal Disease

Arteriovenous Fistula

Department of Nephrology and Transplantation Medicine

Role of Monocytes Adhesion and Vascular Lesions in Vascular Access Success or Failure in Uremic Patients

Blood flow by Doppler ultrasound on brachial artery (ml/min.)

Tomasz Gołębiowski

MD, PhD

Wroclaw Medical University

Universitätsklinikum Halle

Solution containing 75g of glucose diluted in 200 mL of water

Solution containing 75g of fructose diluted in 200 mL of water

Type 1 Diabetes

Glucose

Fructose

University Hospital of Rio de Janeiro, Federal University of Rio de Janeiro

Fructose and Glucose and TAS1R2 in Type 1 Diabetes

Effect of Fructose and Glucose and TAS1R2 in Glucose, Triglycerides, Uremia, Oxidative Stress, Feelings Related to Food Intake of Individuals With Type 1 Diabetes

Determine the blood glucose, triglycerides, oxidation of substrates, uremia, oxidative stress, feelings related to food intake of individuals with type 1 diabetes, before and 3-hours after ingestion of 75g of fructose or 75g of glucose.

Determine the peak plasma blood glucose before and 3-hours after ingestion of 75g of fructose or 75g of glucose.
We also test capillary blood glucose before and 30, 90, 120, and 180 minutes after solutions.

Determine the triglycerides levels before and 3-hours after ingestion of 75g of fructose or 75g of glucose.

Determine the uric acid, pyruvic acid, and lactate levels before and 3-hours after ingestion of 75g of fructose or 75g of glucose.

Determine the malondialdehyde level before and 3-hours after ingestion of 75g of fructose or 75g of glucose.

TAS1R2 (taste receptor, type 1, member 2 T1R2) is the component specific to sweet taste perception, and does not change during the life.
We will determine whether Ser9Cys (dbSNP: rs9701796) and Ile191Val (dbSNP: rs35874116)variations in TAS1R2 were associated with differences the sweet taste perceptions.

Determine the peak plasma blood glucose before and 3-hours after ingestion of 75g of fructose or 75g of glucose.
We also test capillary blood glucose before and 30, 90, 120 and 180 minutes after solutions.

Two different visual analogue scales will be used to assess hunger, satiety, fullness, prospective food consumption, palatability, taste, aftertaste, smell, and visual appeal of the solutions.
The scales will be performed at 7, 35, 95 and 120 minutes after solutions.

Determine the glucagon levels before and 3-hours after ingestion of 75g of fructose or 75g of glucose

Determine the leptin levels before and 3-hours after ingestion of 75g of fructose or 75g of glucose

uremia/triglyceride

Role of Monocytes Adhesion and Vascular Lesions in Vascular Access Success or Failure in Uremic Patients

Fructose and Glucose and TAS1R2 in Type 1 Diabetes

Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure

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