Breast Cancer

honey-based syrup is prepared according to the documented Persian Medicine manuscripts with some modifications. HB is a mixture of honey, rose water and saffron. Each 100g of HB consisted of 79.87 g honey, 19.97 g rose water, and 0.16 g saffron.
All the ingredients were licensed and approved by The Islamic Republic of Iran Food and Drug Organization (I.R.I.FDO).

honey based (HB) syrup

Shohaday-e- Tajrish Hospital

Effects a Honey Based Syrup on Blood Parameters in Patients With Breast Cancer

Honey Based Syrup on Blood Parameters

A mean score of hemoglobin level is generally defined as 12.5 to 14.5 grams per deciliter (125-145 grams per liter) for women. Higher or lower scores mean a worse outcome.

A mean score of WBC count is usually between 4,000 and 11,000 per microliter of blood for women. Higher or lower scores mean a worse outcome.

A mean score of Plt count is usually ranges from 150,000 to 450,000 platelets per microliter of blood for women. Higher or lower scores mean a worse outcome.

Mehdi Pasalar

assistant professor

Shiraz University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Control group consisted of 40 postmenopausal women with normal blood pressure.

Patients received hydrochlorothiazide 25 mg/day p.o. for 1 year.

Patients received perindopril 4 mg/day p.o for 1 year.

Patients received hydrochlorothiazide 25 mg/day p.o. and estrogen-progestin therapy- transdermal patches releasing 17β-estradiol (0.05 mg/24 hours) and norethisterone (0.25 mg/24 hours) for 1 year

Patients received perindopril 4 mg/day p.o and estrogen-progestin therapy- transdermal patches releasing 17β-estradiol (0.05 mg/24 hours) and norethisterone (0.25 mg/24 hours) for 1 year

Patients received estrogen-progestin therapy- transdermal patches releasing 17β-estradiol (0.05 mg/24 hours) and norethisterone (0.25 mg/24 hours) for 1 year.

Hypertension

Hyperuricemia

Menopause

Perindopril

hydrochlorothiazide 25 mg/day p.o. for 12 months

Hydrochlorothiazide

Transdermal patches releasing 17β-estradiol (0.05 mg/24 hours) and norethisterone (0.25 mg/24 hours) for 12 months

Estracomb TTS

Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.

As compared with normotensive women, hypertensive women showed higher office and ambulatory blood pressure, as well as a lower night-time decrease in systolic and diastolic blood pressure.
Both perindopril and hydrochlorothiazide led to a similar reduction in arterial blood pressure in hypertensive women.
After 12 months of treatment, statistically significant differences were observed between the EPT+ and EPT- subgroups in systolic and diastolic office-based blood pressure in the study group treated with ACEI. Such effect of EPT on ABPM(ambulatory blood pressure monitoring) was not observed in all study participants. Multiple linear regression models have shown that after 12 months of antihypertensive treatment there were no significant differences in night-time decrease in blood pressure caused by EPT treatment, despite its significant change when compared to baseline values for ACEI and HCTZ subgroups.

As compared with normotensive women, hypertensive women showed lower GFR and RPF.
Glomerular filtration rate (GFR) remained unaltered in all subgroups throughout the duration of the study. When compared to the baseline values, renal plasma flow (RPF) increased significantly in women treated with perindopril, both with and without EPT. At the end of the study, there were no differences in RPF in the two subgroups of ACEI (EPT+ vs EPT-) groups. RPF also increased in women treated with hydrochlorothiazide and receiving EPT. However, RPF was substantially reduced in the subgroup of women treated with hydrochlorothiazide without EPT.

Hypertensive women had significantly higher serum uric acid levels than normotensive women, whereas clearance and fractional excretion of uric acid were significantly lower in hypertensive than in normotensive women.
Uric acid levels in plasma decreased significantly in women treated with perindopril, both in the subgroup receiving and not receiving hormone replacement therapy (HRT).
At the end of the study, there were no significant differences in plasma uric acid levels in two subgroups treated with ACEI (EPT+ vs EPT-) In hypertensive women treated with hydrochlorothiazide, uric acid concentrations in plasma decreased significantly when compared to the baseline values, but only in the subgroup receiving estrogen-progestin therapy.

In the groups of hypertensive women, serum xanthine and hypoxanthine levels were significantly higher than in the group of normotensive women.
In multivariate analysis, behavior of xanthine and hypoxanthine in the subgroups treated with or without EPT showed significant differences in patients treated with diuretic. In women treated with ACEI with or without EPT, only hypoxanthine levels decreased significantly

Anna Posadzy-Małaczyńska

Habilitated doctor of Medical Sciences in Medicine

Postmenopausal women with, untreated essential hypertension were recruited to the study. The control group consisted of 40 postmenopausal women with normal blood pressure.

drug: olmesartan medoxomil; dosage form: oral tablet; dosage: 20mg/time; frequency: once a day; duration: 4 days

drug1: olmesartan medoxomil; dosage form: oral tablet; dosage: 20mg/time; frequency: once a day; duration: 4 days; drug2: probenecid; dosage form: oral tablet; dosage: 500mg/time; frequency: 2 times/day; duration: 1 day

Drug Interaction of Olmesartan in Healthy Chinese Volunteers

olmesartan medoxomil

olmesartan medoxomil+probenecid

Center of New Drug Clinical Trial, Hunan Provincial Tumor Hospital (The Affiliated Tumor Hospital of Xiangya Medical School of Central South University)

Drug Interaction Study of Olmesartan in Healthy Chinese Volunteers

Effect of Probenecid on Pharmacokinetics, and Tolerability of Olmesartan in Healthy Chinese Volunteers

pharmacokinetic parameters:AUC0-48, AUC0→∞ and Css-av , tmax, t1/2, Css-max, and Css-min

uric acid/borstkanker

Effects a Honey Based Syrup on Blood Parameters in Patients With Breast Cancer

Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.

Drug Interaction Study of Olmesartan in Healthy Chinese Volunteers

Metabolic Syndrome as Modifiable Risk Factor for Breast Cancer

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