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[Whipple disease as a cause of fever of unknown origin].

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Intestinal lipodystrophy (Whipple's disease): a cause of unexplained fever.

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[An elderly patient with arthralgia, fever, weakness and weight loss. Diagnosis of Whipple disease by PCR detection of Tropheryma whippelii].

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Whipple disease.

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Whipple disease (WD) is a rare disease caused by Tropheryma whipplei. The classic profile of the patient is that of a middle-aged man presenting with fever, chronic diarrhea, and arthralgias. Extragastrointestinal manifestations are not rare. A high degree of clinical suspicion for the disease is

Whipple disease revealed by lung involvement: a case report and literature review.

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We report the case of a man with a history of intermittent fever and arthritis who presented with a dry cough and associated lung involvement, who was eventually given the diagnosis of Whipple disease. The pulmonary symptoms preceded the development of GI manifestations. Five years later, periodic

Successful treatment of Whipple disease diagnosed 36 years after symptom onset.

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Whipple disease is a rare infectious disorder with multiorgan manifestations and a widely varied clinical presentation. Involvement of the small intestine with resultant malabsorption is a classic finding, although extraintestinal manifestations such as fever and arthralgias may precede

[Unexplained lymphadenopathy: Whipple disease].

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A 58-year-old man was referred to the internal medicine outpatient department because of abdominal pain and lymphadenopathy. CT imaging revealed multiple mediastinal, para-aortic, mesenteric and pelvic lymphoma. Biopsy of an inguinal lymph node for histology purposes revealed granulomatous

[Neurological manifestations of Whipple disease].

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Whipple disease is an uncommon chronic bacterial infection due to Tropheryma whipplei. Clinical manifestations are protean (joint pain, fever, weight loss, abdominal pain, lymphadenopathies), and the diagnosis is often delayed. Although previously considered a late manifestation of Whipple disease,

Whipple disease: unusual presentation of a protean and sometimes confusing disease.

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OBJECTIVE To describe an unusual case of Whipple disease (WD) with confusing clinical features at onset and to discuss the diagnostic challenges for the clinician. METHODS Description of a new case of this rare disease and thorough discussion of the atypical clinical manifestations at onset. A

Tropheryma whipplei bacteremia during fever in rural West Africa.

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BACKGROUND Tropheryma whipplei not only causes Whipple disease but also is an emerging pathogen associated with gastroenteritis and pneumonia that is commonly detected in stool samples in rural West Africa. We investigated the role of T. whipplei in febrile patients from rural Senegal who had a

Prosopagnosia as the Presenting Symptom of Whipple Disease.

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Whipple disease is a rare, chronic multisystem infectious disease. The central nervous system (CNS) is secondarily involved in 43% of patients; 5% of patients have isolated or primary CNS involvement. The most frequent CNS symptoms are cognitive changes. Prosopagnosia is an inability to recognize

A severe Whipple disease with an immune reconstitution inflammatory syndrome: an additional case of thalidomide efficiency.

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We report the case of a 38-year-old man who presented with severe diarrhea, weight loss of 10 kg, ankles paresthesia and severe motor weakness in the left fibular nerve territory after introduction of azathioprine and corticosteroid for proteinuria. Coloscopy and gastroscopy revealed a typical

Neurocognitive impairment in Whipple disease with central nervous system involvement.

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Young-onset dementias pose a major challenge to both clinicians and researchers. Cognitive decline may be accompanied by systemic features, leading to a diagnosis of "dementia plus" syndromes. Whipple disease is a rare systemic illness characterized by arthralgias, chronic diarrhea, weight loss,

Seronegative Arthritis and Whipple Disease: Risk of Misdiagnosis in the Era of Biologic Agents.

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We report 2 cases of Whipple disease (WD), previously diagnosed as seronegative polyarthritis and treated for several years with immunosuppressive agents, accordingly. Both cases had been treated over years with cDMARDs and bDMARDs. The first patient was a 48-year-old male, who developed a

The immune reconstitution inflammatory syndrome in whipple disease: a cohort study.

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BACKGROUND Whipple disease, which is caused by infection with Tropheryma whipplei, can be treated effectively with antimicrobials. Occasionally, inflammation reappears after initial improvement; this is often interpreted as refractory or recurrent disease. However, polymerase chain reaction for T.

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