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Efficacy, Safety and Tolerability of Ivermectin in Subjects Infected With SARS-CoV-2 With or Without Symptoms

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In late 2019, an unidentified viral pneumonia was detected in Wuhan, China. Later, it was declared that it was pneumonia due to a new coronavirus. The World Health Organization (WHO) officially called it COVID-19 disease (Xie and Chen 2020). Ivermectin is a broad-spectrum antiparasitic agent,

Duration of Immunity 10 Years After a Dose-response Study With Yellow Fever Vaccine - Complementary Study

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This is an observational study in young adult males who received the first dose of the yellow fever vaccine when they participated in the Dose response study of the yellow fever vaccine produced by Bio Manguinhos Fiocruz. The purpose of this study is to know whether reduced dose immunity is

Favipiravir vs Hydroxychloroquine in COVID -19

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Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) and has developed into a pandemic with serious global public health and economic sequelae As of April 27, 2020 over 2,973,000 cases have been confirmed worldwide leading to

Measles and Rubella Vaccine Microneedle Patch Phase 1-2 Age De-escalation Trial

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Using BCG Vaccine to Protect Health Care Workers in the COVID-19 Pandemic

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BACKGROUND Health-care workers face an elevated risk of exposure to - and infection with - SARS-CoV-2. It is imperative to ensure the safety, health and fitness of hospital personnel in order to safeguard continuous patient care. Strategies to prevent COVID-19 or to mitigate its clinical

Hydroxychloroquine vs Nitazoxanide in Patients With COVID-19

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Introduction The current pandemic caused by the SARS-COV2 coronavirus (COVID-19) is life-threatening and is challenging the world's best health systems. Accelerated spread of this pandemia led physicians to try a variety of treatments without a well established sequence due to ignorance about this

Reducing Health Care Workers Absenteeism in Covid-19 Pandemic Through BCG Vaccine

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Since the beginning of 2020, SARS-CoV-2 spread rapidly throughout China and the rest of the world, with on 27 February 2020 the first detected case in the Netherlands. According to the WHO, Health-care workers (HCW) face an elevated risk of exposure to - and infection of Covid-19. Bacillus

Immunisation Status and Safety of Vaccines in Italian MS Patients

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The different available treatments for MS influence the immune system in distinct ways and, therefore, may lead to specific infectious risks. Whereas immunomodulating therapies have no impact on infection risks [Cahill 2010; Winkelmann 2016], the most recent drugs with immunosuppressant activity

The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Vaccination

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The primary aim of this study is to determine the difference between antibody titers in the two study groups and study the relationship between endemic infections, IA, the FRCn, and CD4 and CD8 T cell subsets and the magnitude and durability of neutralizing antibody response to YFV in a cohort shown

Improving Care Through Azithromycin Research for Infants in Africa

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The goal of this project is to improve child survival in areas with high mortality rate. The specific objectives are: Primary: 1. To assess the effect on all-cause mortality up to 18 months of age of AZi administration at 6 weeks and 9 months of age alongside routine EPI immunisations 2. To

Dose-ranging Study of an Investigational Yellow Fever Candidate Vaccine in Adults

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Study duration per participant is approximately 6 months.

Cytotoxicity of Yellow Fever Specific CD8 T Cells Following YF-17D Vaccination

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CD: cluster of differentiation YF: yellow fever

Non- Inferiority Fractional-doses Trial for Yellow Fever Vaccine

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Yellow fever (YF) is a disease caused by a mosquito-borne flavivirus that is endemic in sub-Saharan Africa and tropical South America. Ninety percent of YF cases are in Africa where YF virus is transmitted by different mosquito genera in three recognized transmission cycles. A sylvatic cycle

A Study to Evaluate the Safety, Pharmacokinetics and Antiviral Effects of Galidesivir in Yellow Fever or COVID-19

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This is a randomized, double-blind, placebo-controlled study to evaluate the pharmacokinetics (PK), safety, and antiviral effects of galidesivir administered via intravenous (IV) infusion vs. placebo in hospitalized adult subjects with either Yellow Fever (Group A) or COVID-19 (Group B). The study

Post-Vaccination Biological Collection

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