Screening of Icacina trichantha extracts for pharmacological activity.
Nøkkelord
Abstrakt
Some preliminary studies were conducted on the biological activities of Icacina trichantha in mice. In vitro tests performed with the 70% ethanol, petroleum ether and aqueous extracts of tubers, roots, stems and leaves did not show contraction of isolated guinea pig ileum up to a bath concentration of 40.5 mg/ml. Graded oral doses (100, 200, 400 and 800 mg/kg) of the aqueous extract of tubers produced wet faeces in mice with the number of wet faeces increasing with increasing dose up to 400 mg/kg. A time-course study of the purgative effect showed the maximum purgative response to be 7-8 h after oral dosing. The aqueous extract of tubers significantly potentiated pentobarbital-induced loss of righting reflex at a dose of 80 mg/kg i.p. but this dose did not protect mice from strychnine or leptazole convulsions and death.