Bioorganic and Medicinal Chemistry Letters 2010-Aug
Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line.
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Abstrakt
The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ERbeta binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line.