Bacterial meningitis infection in a mammal is treated by intravenous infusion of a therapeutically effective amount of a monoclonal antibody which binds to tumor necrosis factor alpha and an antibiotic. Treatment can be initiated up to five hours after bacterial challenge and the antibiotic is preferably selected from cephalosporins and aminoglycosides.

Bayer Corporation

Method of treating bacterial meningitis with anti-tumor necrosis factor antibody

Method of treating virus disorders by administering certain compounds, such as benzoyl peroxide, into the blood. Entry of these compounds into the sick cells results in, because of the pH and redox-potential conditions in those cells, oxidation phenomena and deposition of an antiseptic substance in the sick cells, thereby causing cellular aging and necrosis.

Fundacion de Estudios Farmaco-Biologicos

Treatment of cells

It has been newly found out that ascochlorin, which is a publicly known fat-soluble antibiotic, and its homologues serve as a ligand of retinoid X receptor and react in vivo with the amino group of serum protein to form Schiff bases without showing any side effect of retinoid. Ascochlorin and its homologues are usable in treating and/or preventing a disease or condition which can be relieved by the retinoid X receptor ligand-dependent gene transcriptional regulation (for example, diseases caused by the expression of insulin resistance, hypertension, cerebrovascular diseases, rheumatoid arthritis, autoimmune disease, Ca metabolic disorder, complication of diabetes, arteriosclerosis, etc.). Moreover, they can inhibit denaturation and/or necrosis of pancreatic Langerhans islet .beta.-cells and, therefore, are usable in making these cells to sustain the insulin productivity.

Nuclear Receptor Research, Ltd.

Ligands of nuclear receptor

Method of treating virus disorders by administering 1,2-diphenyl-.alpha.,.beta.-diketone into the blood. Entry of this compound into the sick cells results in, because of the pH and redox-potential conditions in those cells, oxidation phenomena and deposition of an antiseptic substance in the sick cells, thereby causing cellular aging and necrosis.

antibiotic/necrosis

Method of treating bacterial meningitis with anti-tumor necrosis factor antibody

Treatment of cells

Ligands of nuclear receptor

Treatment of cells

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