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Efficiency of Methotrexate and Tofacitinib in Mild and Moderate Patients

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The Takayasu arteritis (TAK) is a rare chronic inflammatory arteritis, which lacks effective well-accepted intervention strategy. Previous studies have revealed that methoxamine, tofacitinib, adalimumab, and tocilizumab were effective in controlling disease activity and preventing disease relapse in

A Pilot Study in Severe Patients With Takayasu Arteritis.

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The Takayasu arteritis (TAK) is a rare chronic inflammatory arteritis, which lacks an effective well-accepted intervention strategy. Previous studies have revealed that methotrexate, tofacitinib, adalimumab, and tocilizumab were effective in controlling disease activity and preventing disease

Assessing Feasibility of Thromboprophylaxis With Apixaban in JAK2-positive Myeloproliferative Neoplasm Patients

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Fast Radial Pharmaco-invasive Strategy In ST Elevation Myocardial Infarction Trial

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The FARAD MI will be a randomized, multicenter prospective study will be conducted. Patients with the diagnosis of ST-segment elevation acute myocardial infarction treated at the Sancta Maggiore Emergency Departments who have been thrombolyzed and aged up to 80 years will be included. After

The Prognostic Impact of Using High-dose Hydralazine in Severe Systolic Heart Failure With Hemodynamically Significant Mitral Regurgitation

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Background: The investigator team had focused on heart failure (HF) treatment for many years and tried to develop non-invasive guide for HF treatment. Initially, the investigators had dedicated to use echocardiography to simulate Swan-Ganz and performed validation for non-invasive Swan-Ganz (echo

Screening of Fabry Disease in Patients With GI Symptoms

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Fabry disease screening study in patients diagnosed with gastrointestinal tract (GIT) disease, i.e. with the diagnosis of non-infectious inflammatory bowel disease, functional dyspepsia or irritable bowel syndrome in particular, is a project designed as a pilot study of Centre for Fabry disease,

Achievement and Adherence to Behavioral Health Goals in the Setting of Patient-Directed Goal Choice

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Health care decisions should include patients' health outcome goals and care preferences so as to enable a unified set of individualized patient outcome goals, rather than disparate disease-specific goals that do not reflect patient choice and commitment. This study utilizes a skilled professional

TREAT Foot Drop After Stroke With Ankle Robot

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This study is designed to see if the ankle robot is safe and effective to use in restoring gait function in individuals with foot drop. This research project will be conducted at the University of Maryland Rehabilitation and Orthopaedic Institute (UM Rehab). There will be approximately 10

Predictive Value of HAS-BLED and CHA2DS2-Vasc Scores After PCI

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Dual-antiplatelet therapy (DAPT) with aspirin and an inhibitor of the platelet P2Y12 receptor is necessary to prevent stent-related thrombotic complications after percutaneous coronary intervention (PCI). (1) Although continuation of DAPT confers substantial and durable benefits that extend beyond

Use of Magnetocardiography in Evaluation of Patients Going for Cardiac Catheterization

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This is a multicenter, prospective clinical trial studying the utility and accuracy of magnetocardiography (MCG) in identifying critical coronary artery obstruction responsible for myocardial ischemia. The study will enroll up to 1500 patients at high risk for coronary artery disease (CAD) who have

Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Myocardial Infarction

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Cardiovascular disease is the leading cause of death in the developed world, with global deaths due to coronary artery disease estimated to increase from 7.3 million in 2008 to 25 million by 2020 WHO, 2011. The leading symptom that initiates the diagnostic and therapeutic cascade in patients with

'Understanding the Electrophysiological Substrate Underlying Persistent Atrial Fibrillation Study II (USURP AF- Study II)'

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There are an estimated 1.4 million people in the UK with atrial fibrillation (AF), which accounts for 2.4% of the adult population.1 It is well established that AF is a major causative factor for ischaemic stroke and systemic embolism.2 In addition, strokes resulting from AF carry the highest

Ultrasound Assessment of a Physical Exercise in The Water in a Frail Population

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OBJECTIVE To evaluate changes in muscle architecture by ultrasound, before and after an intervention with physical exercise directed in water in frail individuals; and determine the correlation of the image findings with the changes detected in their morbidity, functionality and quality of

Chest Pain Triage at ED

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Background Acute chest pain triage in the Emergency Department (ED) may prove challenging, since similar symptoms can reveal both mild or life-threatening disorders, and the clinical presentation itself is known not to be reliable for evaluating the risk of acute coronary syndrome (ACS) . The first

Differences in Mortality and Morbidity in Patients Suffering a Time-critical Condition Between GEMS and HEMS

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Background Efficient healthcare can be decisive for patients who suffer an out-of-hospital time-critical medical condition. If untreated these conditions can compromise health and even become life-threatening. The most common time-critical conditions assessed and treated in the prehospital

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