The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant Dysoxylum binectariferum. The compound 5,7-dihydroxy-6-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-- one, is found to be a potential inhibitor of cell growth and proliferation and also inhibits production of pro-inflammatory cytokines. The formulations of this particular compound can be used for treatment of cancer and inflammation. ##STR00001##

Council of Scientific &amp; Industrial Research

COUNCIL OF SCIENTIFIC &amp; INDUSTRIAL RESEARCH

Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders

This invention relates to certain quinolinyl-chromone compounds and their use as valuable pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists possessing anti-inflammatory and anti-allergic properties.

Rorer Pharmaceutical Corporation

Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments

This invention provides compounds defined by Formula I ##STR1##or a pharmaceutically acceptable salt thereof,wherein R.sup.1, Q, Y.sup.2, Y.sup.3, Y.sup.4, U.sup.5, U.sup.6, U.sup.8, and R.sup.2 are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, as defined in the specification, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of inhibiting an MMP-13 enzyme in an animal, comprising administering to the animal a compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention also provides methods of treating a disease mediated by an MMP-13 enzyme in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides methods of treating diseases such as heart disease, multiple sclerosis, osteo- and rheumatoid arthritis, arthritis other than osteo- or rheumatoid arthritis, cardiac insufficiency, inflammatory bowel disease, heart failure, age-related macular degeneration, chronic obstructive pulmonary disease, asthma, periodontal diseases, psoriasis, atherosclerosis, and osteoporosis in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides combinations, comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with another pharmaceutically active component as described in the specification.

chromone/betennelse

Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders

Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments

Chromone derivatives as matrix metalloproteinase inhibitors

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