conception/neoplasms

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Parental employment at time of conception and risk of cancer in offspring.

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Studies on the possible association between exposures of parents at the time off conception and cancer in their offspring have provided no clear answer. In this large, population-based, record-linkage study, 1747 childhood cancer cases were identified in the Danish Cancer Registry and matched with

Lung cancer during pregnancy involving the products of conception and a review of the literature.

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Approximately 1 per 1,000-1,500 pregnancies is complicated by maternal malignancies. Metastatic involvement of the products of conception is a rare event. There have been 62 cases of placental and/or fetal metastatic involvement originating from maternal cancer reported since 1866. Only 14 cases of

Retained products of conception in hysteroscopy in a patient with breast cancer on tamoxifen.

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Tamoxifen is a selective oestrogen receptor modulator widely used in breast cancer treatment, with good survival rates. Its partial agonist action on other tissues such as the uterus, however, promotes the development of endometrial hyperplasia and cancer. It appears that tamoxifen does not alter

Supporting Supportive Care in Cancer: The ethical importance of promoting a holistic conception of quality of life.

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Advances in anticancer therapies and increasing attention towards patient quality of life make Supportive Care in Cancer (SCC) a key aspect of excellence in oncological care. SCC promotes a holistic conception of quality of life encompassing clinical, ethical/existential, and spiritual dimensions.

Evolutionary malignant resistance of cells to damaging factors as common biological defence mechanism in neoplastic development. Review of conception.

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Cells have some inborn resistance to harmful factors, which could be called physiological or natural resistance. The mechanisms of multixenobiotic resistance (MXR) and multidrug resistance (MDR) have common features in the formation of acquired resistance in microorganisms, carcinogenesis, tumour

No increased risk of relapse of breast cancer for women who give birth after assisted conception.

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Is childbirth after IVF associated with a risk of relapse in breast cancer?Women who had been diagnosed with breast cancer and completed treatment had no increased risk of relapse if they gave birth after conceiving with

Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model.

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Prostate cancer (PCa) is one of the most common cancers in older men and is associated with high mortality. Despite advances in screening for early detection of PCa, a large proportion of patients continue to be diagnosed with metastatic disease, with ~20% of men showing a high tumor grade and

Conception and stages of development of the microbiological cancer test.

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Pathology and experimental bacteriology have, in scientific medicine, created fundamental methodical presuppositions for the description and recognition of etiologic entities. With the tumour-tetanus phenomen, two pathogenic principles--cancer growth and tetanus infection--coincide in a so far

Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models.

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Tumor heterogeneity and drug resistance pose severe limitations to chemotherapy of colorectal cancers (CRCs) necessitating innovative approaches to trigger multiple cytocidal events for increased efficacy. Here, we developed a hybrid drug called KSS19 by combining the COX-2 selective NSAID rofecoxib

Can conception of prostate cancer stem cells influence treatment dedicated to patients with disseminated disease?

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No survival profit has been achieved for patients with disseminated prostate cancer since hormonal therapy was introduced. It is proposed that dissemination of rare prostatic cancer stem cells may lead to metastatic disease and that resistance of these cells to androgen ablation makes them

[Detection of oral cancers and current conception of precancerous conditions].

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Detection and early diagnosis of oral cancers are conducted by general practitioners and dentists. Oral examination is particularly simple: it must be conducted methodically, helped with a good topographical knowledge. Oral examination allows to recognize cancers among tumorous oral lesions based on

Pregnancy after breast cancer: from psychosocial issues through conception.

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Women face numerous issues if they either contemplate childbearing or become pregnant after the diagnosis of breast cancer. Based on a search of the English medical literature from 1966 to 1997, we make the following conclusions regarding pregnancy after breast cancer: (1) Sexual function is not

[Adjuvant chemotherapy in the conception of multimodal cancer treatment (author's transl)].

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Without any doubt remarkable progress in the field of adjuvant cancer chemotherapy after local-regional treatment has been achieved during the last decade. Nevertheless the real results are behind our expectations basing on theoretical and experimental considerations. Therefore adjuvant cancer

Conception and Management of a Poorly Understood Spectrum of Dermatologic Neoplasms: Atypical Fibroxanthoma, Pleomorphic Dermal Sarcoma, and Undifferentiated Pleomorphic Sarcoma.

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Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) tumors share many clinical, etiologic, and histologic features and likely represent components of a tumor spectrum. In dermatologic oncology, differentiating between AFX and PDS is pivotal as tumors with histological features

Birth Outcomes in Children Fathered by Men Treated with Anti-TNF-α Agents Before Conception.

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The safety of paternal use of anti-tumor necrosis factor-α (TNF-α) agents immediately prior to conception is practically unknown. On the basis of nationwide data from Danish health registries, we examined the association between paternal use of anti-TNF-α agents within 3 months before conception and

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