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Specific gravity increases and brain water content decreases during short epileptiform seizures in discrete rabbit brain areas.

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In rabbits subjected to bicuculline (BC)- or pentylenetetrazole (PTZ)-seizures of 3 or 20 min duration or to adrenaline-induced hypertension, specific gravity (SG) was measured bilaterally in 15 regional brain areas in order to detect possible associations between the regionally limited blood-brain

Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures.

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It is still a question of much debate whether single epileptic seizures can cause cell loss. Despite the clinical impression that epilepsy in general is a progressive disorder, experimental evidence is not conclusive on this point. Recently, it has been shown that electrically-induced

[Epilepsy and pregnancy--drug use, seizure control, and complications].

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BACKGROUND There is insufficient knowledge about the effect of epilepsy and epilepsy treatment on pregnancy, and vice versa. The European Registry of Antiepileptic drugs and Pregnancy (EURAP) was therefore established in 1999. We here present the results from the Norwegian part of the study, with

Do women with epilepsy benefit from epilepsy specific pre-conception care?

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To determine how pre-conception care (PCC) influenced the outcome of epilepsy, pregnancy and malformation risk in women with epilepsy (WWE).All primigravida in the Kerala registry of epilepsy and pregnancy (KREP) with the final outcome of pregnancy known

ACOG educational bulletin. Seizure disorders in pregnancy. Number 231, December 1996. Committee on Educational Bulletins of the American College of Obstetricians and Gynecologists.

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With close cooperation and communication among the obstetrician, neurologist, pediatrician, and patient, most women with idiopathic epilepsy who become pregnant will have an uneventful pregnancy with an excellent outcome. To optimize the neonatal outcome in a patient requiring medication, using a

Influences on seizure activity in pregnant women with epilepsy.

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This study evaluated whether referral to a specialized epilepsy clinic prior to pregnancy influences seizure activity during pregnancy. In addition, folic acid supplementation prior to pregnancy as a marker of intent to conceive was used to evaluate whether the use of folic acid at the time of

The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings.

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Caffeine, a central nervous system stimulant, has been reported to modulate seizure activity in various studies. In this study the effects of caffeine exposure on the pentylenetetrazole (PTZ) induced seizure thresholds and seizure stages in the Wistar and genetic absence epilepsy model offsprings

Effect of cross-fostering on seizures in adult male offspring of methamphetamine-treated rat mothers.

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Stimulant drugs are often associated with increased seizure susceptibility. Inhibitory gamma-aminobutyric acid (GABA) and excitatory N-methyl-D-aspartate (NMDA) systems play a role in the effect of stimulants in the genesis of epileptic seizures. Our previous studies showed that prenatal

CSF findings in neonates with seizures; infectious and noninfectious.

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In order to evaluate parameters of cerebrospinal fluid (CSF) we studied 105 CSF samples of 50 neonates with seizures of unknown origin for cell count and chemistry (protein, albumin, glucose, IgG-index and albumin-ratio). Viral studies for 13 different microbes were performed from serum and CSF. CSF

Fall conception increases the risk of neurodevelopmental disorder in offspring.

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Hormonal imbalances in utero may render males more vulnerable to neurodevelopmental disorder (ND) than females. Since hormonal activity can be influenced by photoperiod, the relationship between season of conception and incidence of ND in offspring was examined within 11,578 mother/child pairs. Fall

Electroshock seizures protect against apoptotic hippocampal cell death induced by adrenalectomy.

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Seizures evoked by electroshock induce rapid changes in the expression of several genes in the adult brain, including those encoding for neurotrophic factors. Some of the neurotrophic factors induced by brief seizures such as basic fibroblast growth factor and nerve growth factor have been shown to

Long-term fish oil supplementation attenuates seizure activity in the amygdala induced by 3-mercaptopropionic acid in adult male rats.

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Several studies have provided evidence of significant effects of omega-3 fatty acids on brain functionality, including seizures and disorders such as epilepsy. Fish oil (FO) is a marine product rich in unsaturated omega-3 fatty acids. Considering that the amygdala is one of the brain structures most

Increased seizure susceptibility induced by prenatal methamphetamine exposure in adult female rats is not affected by early postnatal cross-fostering.

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Our previous studies repeatedly demonstrated that prenatal methamphetamine (MA) exposure alters seizure susceptibility in adult rats. Both the inhibitory GABA system and the excitatory NMDA system play a role in the effect of MA on epileptic seizures. On the basis of our previous behavioral results,

Consequences of recurrent seizures during early brain development.

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It is well documented that prolonged seizures (status epilepticus) can cause neuronal injury and result in synaptic reorganization in certain brain regions. However, the effect of recurrent, relatively short seizures in young animals on subsequent brain development is not known. To study the

A de novo, apparently balanced reciprocal translocation in a child with developmental delay whose mother was being treated with low-dose methotrexate at the time of conception.

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BACKGROUND Methotrexate is a proven teratogen and its use periconceptually is strongly advised against. Concerns about possible chromosomal effects in the offspring of women treated with this agent have been raised, but they have not been reported. In vivo and in vitro studies have supported this

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