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Indoor secondary organic aerosols formation from ozonolysis of monoterpene: An example of d-limonene with ammonia and potential impacts on pulmonary inflammations.

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Monoterpene is one class of biogenic volatile organic compounds (BVOCs) which widely presents in household cleaning products and air fresheners. It plays reactive role in secondary organic aerosols (SOAs) formation with ozone (O3) in indoor environments. Such ozonolysis can be influenced by the

Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans.

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OBJECTIVE To further explore the anti-inflammatory properties of d-Limonene. METHODS A rat model was used to compare evolution of TNBS (2,5,6-trinitrobenzene sulfonic acid)-induced colitis after oral feeding with d-Limonene compared to ibuprofen. Peripheral levels of TNF-α (Tumor Necrosis Factor

D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways.

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D-limonene has been demonstrated to have important immunomodulatory properties, including antitumor effects, and may alleviate asthma and allergies. In the present study, the anti‑inflammatory effects of D‑limonene were investigated in an ulcerative colitis (UC) rat model. Healthy male

D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.

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D-Limonene, a common monoterepene has been shown to have antiproliferative, apoptosis-inducing and chemopreventive effects. In the present study, we have investigated the effects of D-limonene on the growth of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate

D-limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats.

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D-limonene is a naturally occurring monoterpene and has been found to posses numerous therapeutic properties. In this study, we used D-limonene as a protective agent against the nephrotoxic effects of anticancer drug doxorubicin (Dox). Rats were given D-limonene at doses of 5% and 10% mixed with

Effects of the autophagy modulators d-limonene and chloroquine on vimentin levels in SH-SY5Y cells

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The molecular target and mechanism by which d-limonene induces LC3 lipidation and autophagosome formation remain elusive. Here, we report that this monoterpene rapidly enhances Ca²⁺ levels in SH-SY5Y cells; yet this effect does not lead to calpain- or caspase-mediated proteolysis of

Anti-stress effects of d-limonene and its metabolite perillyl alcohol.

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Stress is closely linked by its biological mechanisms to inflammation and by its consequences to accelerated aging. Stress triggers a hormonal response along the hypothalamus-pituitary-adrenal (HPA) axis, which can disrupt the ortho/parasympathetic balance essential for a harmonious life. Proper

Antifibrotic effects of D-limonene (5(1-methyl-4-[1-methylethenyl]) cyclohexane) in CCl4 induced liver toxicity in Wistar rats.

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This study was designed to assess the potential antifibrotic effect of D-Limonene-a component of volatile oils extracted from citrus plants. D-limonene is reported to have numerous therapeutic properties. CCl4 -intduced model of liver fibrosis in Wistar rats is most widely used model to study

D-Limonene mitigate myocardial injury in rats through MAPK/ERK/NF-κB pathway inhibition.

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Cardiovascular diseases are the primary reason of mortality, among which myocardial infarction (MI) is the most dominant and prevalent. This study was considered to examine D-Limonene protective action against isoproterenol (ISO) induced MI. Wister male rats were dispersed into four groups. Normal

D-Limonene mitigate myocardial injury in rats through MAPK/ERK/NF-κB pathway inhibition.

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[Studies on tissue compatibility of d-limonene as a dissolving agent of cholesterol gallstones (author's transl)].

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A 97% d-limonene preparation was injected as a bolus into the biliary tract of cats. Depending on volume, contact time, and flow direction of the solution, acute or chronic inflammatory damages for varions degrees were found in the hepatobiliary tissues of all animals treated with the d-limonene

Limonene and its ozone-initiated reaction products attenuate allergic lung inflammation in mice.

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Inhalation of indoor air pollutants may cause airway irritation and inflammation and is suspected to worsen allergic reactions. Inflammation may be due to mucosal damage, upper (sensory) and lower (pulmonary) airway irritation due to activation of the trigeminal and vagal nerves, respectively, and

Skin repair properties of d-Limonene and perillyl alcohol in murine models.

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The orange-peel derived terpene d-Limonene, probably through its metabolite, perillyl alcohol (POH), has been reported to have tissue-repair properties. Two murine models of respectively 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-induced dermatitis and mechanical skin lesion were used here to assess

Application of D-Limonene as a Bio-based Solvent in Low Density-Dispersive Liquid-Liquid Microextraction of Acidic Drugs from Aqueous Samples.

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This study deals with the application of different monoterpenes as relatively green bio-based solvents for low density-dispersive liquid-liquid microextraction (LD-DLLME) of different non-steroidal anti-inflammatory drugs (NSAIDs) from aqueous samples in comparison with conventional halogenated

Citrus oil and MgCl2 as antibacterial and anti-inflammatory agents.

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BACKGROUND The antibacterial and anti-inflammatory properties of Dead Sea magnesium chloride (MgCl(2)), citrus oil, and their combination were investigated. Citrus oil is composed of monoterpenes, in particular D-limonene, which is known to inhibit growth of bacteria, fungi, and certain

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