Twelve patients found to be colonized with C. difficile will undergo twice a day potato starch supplementation.

Clostridium Difficile

Hematologic Diseases

Potato starch will be given twice a day for up to 14 days, discharge, or death, whichever occurs first.

Potato starch

Medical College of Wisconsin

Oligosaccharide for Cdiff(+) Heme-onc Patients

Oligosaccharide Supplementation Among Hematology-Oncology Clostridium Difficile Colonized Patients

Samples will be collected twice a week (4-5 times during supplementation) and one time at day 21 or discharge, whichever happens first.

Patients will be provided with a diary in which they will document compliance with oligosaccharide intake. It is anticipated ≥70% of intended doses to be fully administered by the patient.

It is expected ≥50% of stool samples to be correctly collected and processed.

Stool samples collected for diagnosis and any additional stool collections will be thawed in batches and one cc aliquot will be extracted refreezing the remaining sample at -80 degrees F. One cc aliquot will then be divided into 4 sub-samples of equal volume and with the same unique identifier. This identifier will be able to chronologically cluster samples by each unique patient. A sample will be used for C. difficile qPCR quantitative determination.

Sub-sample of stool from diagnosis, and additional stool collections will be used for 16S ribosomal ribonucleic acid gene sequencing to determine the microbiome community structure

Siliva Munoz-Price

Professor

30 g of MSPrebiotic (potato resistant starch) per day taken with 1 glass (approximately 250 mL) of non-heated fluid or non-heated semi-solid food. If the participant is taking any medications, they will be advised to either take the product 2 hours before or 2 hours after any medications.

30 g of corn starch per day taken with 1 glass (approximately 250 mL) of non-heated fluid or or non-heated semi-solid food. If the participant is taking any medications, they will be advised to either take the product 2 hours before or 2 hours after any medications.

30 g of MSPrebiotic (potato resistant starch) per day taken with 1 glass (approximately 250 mL) of non-heated fluid. If the participant is taking any medications, they will be advised to either take the product 2 hours before or 2 hours after any medications.

30 g of corn starch per day taken with 1 glass (approximately 250 mL) of non-heated fluid. If the participant is taking any medications, they will be advised to either take the product 2 hours before or 2 hours after any medications.

Focus of Study; Impact of MSPrebiotic on Gastrointestinal Microbiota

MSPrebiotic

St. Boniface Hosptial Research Centre

Deer Lodge Centre

Effects of MSPrebiotic on Gut Health in the Elderly

Changes from baseline in the tolerability of ingestion of 30 g once/day of MSPrebiotic with respect to gastrointestinal side effects (excessive flatulence, changes in bowel movements, abdominal pain and bloating) at 2, 6, 10 and 14 weeks.

Changes from baseline in gut health improvements including: reduced constipation (i.e. improved ease of bowel movements without stool softeners), microbiome composition (i.e. favourable Firmicutes to Bacteroides ratio) at 2, 6, 10 and 14 weeks.

Changes from baseline of short chain fatty acid levels in stool including; acetate, propionate, butyrate, isobutyrate, valerate, isovalerate at 2, 4, 6, 10 and 14 weeks.

Changes from baseline of Inflammatory marker (IL-10, C-reactive protein, TNFα) levels in blood at 2, 6, 10 and 14 weeks.

This will be assessed based on completion of a daily health log that assesses a wide variety of parameters.

Dr. Michelle Alfa

Principal Investigator

St. Boniface General Hospital Research Centre

National Microbiology Laboratory, Canada

Manitoba Starch Products

Kyo-Dophilus (5x109 bacteria/capsule, twice a day, 1 in the morning, 1 in the evening)

diarrhea/potato

Oligosaccharide for Cdiff(+) Heme-onc Patients

Effects of MSPrebiotic on Gut Health in the Elderly

Effects of Probiotics in Patients With Ulcerative Colitis

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