Bifidobacterium lactis M8 at 10 log CFU/day for 4 weeks

Intervention consists of daily administration of 1g of maltodextrin, administered daily for 4-weeks

Respiratory Infection (for Example, Pneumonia, Bronchitis)

Oral administration of B. lactis M8 at 10 log CFU/day for 4-weeks

Probiotic

Oral administration of maltodextrin daily for 4-weeks

Placebo

Hospital USM

Treatment of Upper and Lower Respiratory Tract Infections in Young Children Using Probiotic

Differences in duration of hospitalization in young children with respiratory tract infections upon administration of B. lactis M8 at 10 log CFU/day compared to placebo

Differences in clinical symptoms scores of young children with respiratory tract infections upon administration of B. lactis M8 at 10 log CFU/day compared to placebo

Differences in gastrointestinal symptoms scores of young children with respiratory tract infections upon administration of B. lactis M8 at 10 log CFU/day compared to placebo

Differences in microbiota abundance of saliva and fecal sample in young children with respiratory tract infections upon administration of B. lactis M8 at 10 log CFU/day compared to placebo

Differences in concentrations of protein such as interleukins (IL-10, IL-4, IL-6, TNF-alpha, IFN-gamma) in saliva (ug/mL) and fecal (ug/mg) sample in young children with with respiratory tract infections upon administration of B. lactis M8 at 10 log CFU/day compared to placebo

Differences in gene expressions for inflammation (IL-10, IL-4, IL-6, TNF-alpha, IFN-gamma), immunity (T-cell and B-cell) in unit of fold change or delta-delta CT values, of saliva and fecal sample in young children with respiratory tract infections upon administration of B. lactis M8 at 10 log CFU/day compared to placebo

Min-Tze LIONG

Prof. (Clinical Professor)

Universiti Sains Malaysia

Beijing Scitop Bio-Tech Shareholding Co.Ltd.

Intervention consists of daily administration of 2g probiotic Lactobacillus plantarum DR7, administered daily at a fixed dosage of 9 log CFU/sachet/day and continue for 12 weeks.
Intervention: Dietary Supplement: Lactobacillus plantarum DR7

Intervention consists of daily administration of 2g placebo (no probiotic bacteria), administered daily and continue for 12 weeks.
Intervention: Dietary Supplement: Placebo

Stress

This project aims to study the benefits of probiotics namely Lactobacillus plantarum DR7 for brain health benefits primarily to alleviate stress, among adults in Malaysia aged from 18-60 years. Secondary emphases include respiratory and gastrointestinal health

Lactobacillus plantarum DR7

School of Industrial Technology, Universiti Sains Malaysia

Lactobacillus Plantarum DR7 for Gut-Brain-Axis Benefits

To evaluate the potential of oral administration of Lactobacillus plantarum DR7 in alleviation of stress using PSS questionnaire

To evaluate the potential of oral administration of Lactobacillus plantarum DR7 in alleviation of depression using DASS42 questionnaire

To evaluate the potential of oral administration of Lactobacillus plantarum DR7 in enhancing cognition ability using Cogstate Brief Battery

To evaluate the potential of oral administration of Lactobacillus plantarum DR7 in reducing upper respiratory episodes and symptoms using illness symptom chart

To evaluate the potential of oral administration of Lactobacillus plantarum DR7 in reducing diarrhea incidents using illness symptom chart

To evaluate the potential of oral administration of Lactobacillus plantarum DR7 in enhancing immunity via blood cytokines analyses

Professor Dr.

Clinical Nutrition Sdn Bhd

Placebo and DR7 will be administered via a parallel design

Masking will be subjected to Participant, Care Provider, Investigator

This is a single arm study all subjects will receive the study VSL#3 probiotic. Subjects will take 1 sachet of powder orally daily for 12 weeks

Other: VSL#3® probiotic VSL#3® DS (Sigma-Tau Pharmaceuticals) is a well characterized water soluble, live (9 × 1011 bacteria/sachet), lyophilized preparation of 8 probiotic bacterium that have been detailed previously. Subjects will take 1 sachet of powder orally daily for 12 weeks. As many Malian homes lack refrigeration, subjects will be issued a special "canari", a commonly used earthenware water container also containing sand that works on the principal of "trans-evaporation" to keep contents at room temperature (~24°C) even in warmer climates. We have verified this in country. Probiotics will be placed in a sealed plastic bag within a sealed jar in the sand of the canari. At the research site, probiotics will be kept refrigerated (4-8°C) in a study provided refrigerator

VSL#3® probiotic

Nianankoro Fomba Hospital

Pilot Study of Oral Probiotic Bacteria Supplementation to Reduce Chronic Immune Activation in HIV-infected Malian Women

A Pilot Study of Oral Probiotic Bacteria Supplementation to Reduce Microbial Translocation and Chronic Immune Activation in HIV-infected Malian Women

sCD14 is marker of monocyte response to endotoxin associated with mortality

sCD163 is a marker of monocyte activation associated with cardiovascular disease (CVD)

IL-6 is associated with mortality and CVD

d-dimer is associated with mortality and CVD

intestinal fatty acid biding protein is associated with gut epithelial cell injury

immunostimulator/diarrhea

Treatment of Upper and Lower Respiratory Tract Infections in Young Children Using Probiotic

Lactobacillus Plantarum DR7 for Gut-Brain-Axis Benefits

Pilot Study of Oral Probiotic Bacteria Supplementation to Reduce Chronic Immune Activation in HIV-infected Malian Women

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