Pancreatic Necrosis

serum mitochondrial DNA will be measured using RT-PCR within first 72 hours of symptoms of acute pancreatitis

serum mitochondrial DNA

Predicting Pancreatic Necrosis Using mitDNA

Study of Plasma mitDNA in Predicting Pancreatic Necrosis in Acute Pancreatitis

level of serum mitochondrial DNA in severe acute pancreatitis

Soha Mohammad Nageb

spechialist

Assiut University

intradermal injection (15ug hemagglutinin 2013/2014 trivalent influenza vaccine) delivered with the Intanza, single dose injection

intramuscular injection (15ug hemagglutinin 2013/2014 trivalent influenza vaccine) delivered with the Vaxigrip, single dose injection

Influenza, Human

Principal Investigator would be responsible for injecting the intradermal vaccine in a sterile technique.

Intanza

Principal Investigator would be responsible for injecting the intrmuscular vaccine in a sterile technique.

Vaxigrip

Queen Mary Hospital and Fung Yiu King Hospital, Hong Kong West Cluster, Hospital Authority

Safety and Efficacy of Intradermal Trivalent Influenza Vaccination in Institutionalized Older Adults

Neutralization antibody titre against the 3 influenza viruses are tested 3 times at day 0, day 21 and day 180 of vaccination for comparison. The titer of neutralization antibody is defined as the maximum dilution of serum at which the percentage of cytopathic effect is less than or equal to 50%.

Adverse effects due to vaccination from day 0 to day 7 will be recorded. Adverse effects boardly divided into local and systemic. Local adverse effect include swelling, erythema, pruritis, pain. Systemic adverse effect include fever, malaise, myalgia

Dr. Chan Tuen Ching

Resident Specialist

The University of Hong Kong

One 1.6 mg subcutaneous injection of the adjuvant, poly ICLC, in the upper arm.

Healthy Volunteers

One 1.6 mg subcutaneous injection of the study drug, poly ICLC in the upper arm.

Poly ICLC

The Rockefeller University

Polyinosinic-Polycytidylic Acid-poly-L-lysine Carboxymethylcellulose (Poly-ICLC) in Healthy Volunteers

An Open Label Study to Evaluate Innate Immune Responses Induced by a Pattern Recognition Receptor Agonist, Poly-ICLC (Hiltonol), in Healthy Volunteers

The variables to be assessed include:
Transcriptional arrays in whole PBMCs and in 8 subsets of blood leukocytes (naïve and memory T, NK, B, monocytes and three different subsets of dendritic cells (BDCA1+, BDCA3+ and BDCA2+ plasmacytoid DCs) following s.c. administration of poly ICLC.
Flow cytometric analysis of activation markers in different subsets of blood leukocytes.
Measurement of cytokines in the serum and/or plasma following s.c. administration of poly ICLC.

The following variable will be assessed:
- Transcriptional analysis of whole PBMC samples at different timepoints following the first dose and the second dose of poly ICLC in volunteers who participated in protocol MAC-682 and are now returning to participate in this proposed study.

The following will be assessed:
Routine histology and immunohistochemistry to evaluate cellular infiltrates following subcutaneous injection of poly ICLC.
Transcriptional analysis of skin samples from study drug injection site and from a non-lesional site of skin.

immunostimulator/hemorrhage

Predicting Pancreatic Necrosis Using mitDNA

Safety and Efficacy of Intradermal Trivalent Influenza Vaccination in Institutionalized Older Adults

Polyinosinic-Polycytidylic Acid-poly-L-lysine Carboxymethylcellulose (Poly-ICLC) in Healthy Volunteers

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