Mutant strains have been isolated from Streptococcus mutans strain BHT-2(str) which are characterized by a single point mutation in the structural gene for the enzyme, L(+) lactate dehydrogenase, this enzyme being normally responsible for lactic acid production by this bacterium. Streptococcus mutans is believed to be a principal pathogen in dental caries, a disease characterized by the dissolution of the mineral portion of the tooth caused by acid resulting from the interaction of bacteria on the tooth surface with carbohydrates. The mutant strains of the invention will be found useful as prototype nonvirulent effector strains in controlling the incidence and severity of dental caries.

Forsyth Dental Infirmary for Children

Lactate dehydrogenase mutants of Streptococcus mutans

Method of controlling dental caries with streptococcus mutans mutant strains

Edible or oral compositions which limit the promotion of tooth decay and comprise lactate dehydrogenase and sucrose-inverting enzymes. Included among such compositions are foods containing 0.1 to 2% water and either sugar or sugar substitutes. Foods without sugars and pharmaceutical preparations are also included in the scope of this invention.

Ferrero GmbH

Edible or oral compositions

Edible or oral compositions which limit the development of tooth decay and comprise lactate dehydrogenase. Included among such compositions are foods containing 0.1 to 2% of water and either sugar or sugar substitutes. Foods without sugar and pharmaceutical preparation are also included in the scope of this invention.

lactate dehydrogenase/dental caries

Lactate dehydrogenase mutants of Streptococcus mutans

Method of controlling dental caries with streptococcus mutans mutant strains

Edible or oral compositions

Oral or edible compositions

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