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Side 1 fra 27 resultater
Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44)
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FIELD OF THE INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists
Method of using a gastrointestinal stimulator device for digestive and eating disorders
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BACKGROUND OF THE INVENTION
Gastrointestinal stimulation, or pacing, was advocated as a possible treatment for gastric motor dysfunction as early as 1963. Experimentation in the late 1960s and early 1970s, began to demonstrate the significance of gastrointestinal myoelectrical activity and its
Modulation of substance P by compounds containing calcium sulfate and methods relating thereto
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TECHNICAL FIELD
The present invention relates generally to a method of modulating substance P by compounds containing calcium sulfate, particularly syngenite, gorgeyite and gypsum, and more specifically, to the synthesis of such compounds as well as their use to treat a variety of conditions
Deuterium-enriched pyridinonecarboxamides and derivatives
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SUMMARY OF THE INVENTION
The present invention is concerned with deuterium-enriched pyridinone carboxamides and derivatives thereof of formula I,
##STR00002##
Wherein, R.sub.1 and R.sub.2 are independently, H, D (deuterium with enrichment of 1%-100%), F, Cl, CD.sub.3 (methyl-d.sub.3),
Deuterium-enriched pyridinonecarboxamides and derivatives
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SUMMARY OF THE INVENTION
The present invention is concerned with deuterium-enriched pyridinonecarboxamides and derivatives thereof of formula 1,
##STR00002## Wherein, R.sub.1 and R.sub.2 are independently, H, D (deuterium with enrichment of 1%-100%), F, Cl, CD.sub.3 (methyl-d.sub.3),
Methods of screening for agonists and antagonists of the interaction between the human KIAA0001 receptor and ligands thereof
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FIELD OF THE INVENTION
This invention relates to methods for discovering agonists and antagonists of the interaction between UDP-sugars (e.g.,UDP-glucose, UDP-galactose, UDP-glucuronic acid, and UDP-N-acetyl glucosamine) and their cellular receptor, human KIAA0001 receptor. The invention also
Sulphonamide derivatives, their preparation and their therapeutic application
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FIELD OF THE INVENTION
The present invention relates to sulfonamide derivatives, to the process for preparing them and to their therapeutic use.
BACKGROUND OF THE INVENTION
Orexins A and B (or hypocretins 1 and 2) are hypothalamus neuropeptides of 33 and 28 amino acids, respectively, recently
Nucleic acid encoding a bovine calcitonin receptor-like receptor (BECRLR)
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FIELD OF THE INVENTION
This invention relates to newly identified polypeptides and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds that may be agonists or antagonists that are potentially useful in therapy, and to production of such polypeptides and
Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine is a neurotransmitter found in various parts of the central nervous system. It is most prevalent in the substantia nigra (A9), the neostriatum, and the ventral tegmental area (A10). Dopamine binds to two general classes of receptors, termed D1- and D2-like
Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine is a neurotransmitter found in various parts of the central nervous system. It is most prevalent in the substantia nigra (A9), the neostriatum, and the ventral tegmental area (A10). Dopamine binds to two general classes of receptors, termed D1- and D2-like
Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine is a neurotransmitter found in various parts of the central nervous system. It is most prevalent in the substantia nigra (A9), the neostriatum, and the ventral tegmental area (A10). Dopamine binds to two general classes of receptors, termed D1- and D2-like
Ligands for monoamine receptors and transporters, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
Ligands for monoamine receptors and transporters, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
Ligands for monoamine receptors and transporters, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
4-substituted piperidines, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in
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