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Functional Analysis of Protein Tyrosine Phosphatases in Thrombosis and Hemostasis.

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Platelets are small blood cells derived from cytoplasmic fragments of megakaryocytes and play an essential role in thrombosis and hemostasis. Platelet activation depends on the rapid phosphorylation and dephosphorylation of key signaling molecules, and a number of kinases and phosphatases have been

Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.

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BACKGROUND A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. A better understanding of the molecular mechanisms leading to platelet activation is important for the development of improved therapies. Recently, protein tyrosine

Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth.

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Platelets are critical for normal hemostasis. Their deregulation can lead to bleeding or to arterial thrombosis, a primary cause of heart attack and ischemic stroke. Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is a 5-phosphatase capable of dephosphorylating the

Serum alkaline phosphatase is a predictor of mortality, myocardial infarction, or stent thrombosis after implantation of coronary drug-eluting stent.

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OBJECTIVE The association between alkaline phosphatase (ALP) and mortality was reported in several subgroups of patients. But, the role of ALP in overall coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI) remains unknown. The aim of this study was to examine the

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis.

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Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke. Platelet adhesion, activation, and aggregation at sites of vascular injury are regulated by a

Experimental thrombosis in rabbits: evidence that alkaline phosphatase enhances the thrombogenic effect of the injected ellagic acid.

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Thrombosis of the vena cava and hepatic veins (Chiari's syndrome) in a patient with nephrosis; report of a case and observation on serum phosphatase and prothrombin time of plasma.

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CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo.

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Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. CEACAM1 possesses adhesive and signaling properties mediated by its intrinsic immunoreceptor tyrosine-based inhibitory motifs that recruit

Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.

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OBJECTIVE Platelets express a functional ubiquitin-proteasome system. Mass spectrometry shows that platelets contain several deubiquitinases, but whether these are functional, modulate the proteome, or affect platelet reactivity are unknown. RESULTS Platelet lysates contained ubiquitin-protein

Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation.

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Inorganic polyphosphates are linear polymers of orthophosphate that modulate blood clotting and inflammation. Polyphosphate accumulates in infectious microorganisms and is secreted by activated platelets; long-chain polyphosphate in particular is an extremely potent initiator of the contact pathway,

Diffuse cholangiocarcinoma presenting with hepatic failure and extensive portal and mesenteric vein thrombosis.

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A 64-year-old previously healthy man presented with a 4-week history of vague right upper quadrant abdominal pain. Imaging studies revealed extensive portal, splenic, superior and inferior mesenteric vein thrombosis with mosaic perfusion and wedge-shaped areas of liver perfusion abnormalities. An

New developments in thrombosis and coagulation therapy.

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The 15(th) International Congress on Thrombosis (Mediterranean League against Thromboembolic Disease), held October 16-21, 1998, in Antalya, Turkey, brought researchers and clinicians up to date on the latest developments in thrombosis, hemostasis, coagulation and hematology, including epidemiology,

Blood cells diseases and thrombosis.

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OBJECTIVE In recent years knowledge about thrombophilia and the mechanisms underlying the pathogenesis of thrombosis has increased greatly. Nevertheless the role of leukocytes and red cells in thrombogenesis is not well established and is probably underestimated. METHODS The contribution of

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.

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Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase (Csk) and receptor-like protein tyrosine-phosphatase CD148 in mice results in a dramatic increase

The assessment of pancreatic exocrine function by bentiromide test in patients with chronic portal vein thrombosis.

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BACKGROUND It has been noted in the literature that cavernous transformation of the portal vein (CTPV) can cause pancreatic duct atrophy, probably by enhanced collateral formation, but the clinical significance of this has not been established. OBJECTIVE To evaluate whether CTPV affects the

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