Phytomedicine 1996-Mar
Angiotensin converting enzyme (ACE) inhibitory flavonoids from Erythroxylum laurifolium.
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In our screening program for antihypertensive properties of plants in traditional use, the 99% ethanol extract of Erythroxylum laurifoiium leaves showed interesting angiotensin converting enzyme (ACE) inhibitory activity. The activity was found to be due to proanthocyanidins or condensed tannins and the flavonoids quercetin-3-O-rhamnoside (quercitrin) (IC(50) = 0.67 mM) and kaempferol-3-O-rhamnoside (afzelin) (IC(50) = 2.8 mM). In addition, quercitrin with afzelin demonstrated in vitro synergistic ACE inhibitory activity.
