Comparative Heating Efficiency of Cobalt-, Manganese-, and Nickel-Ferrite Nanoparticles for a Hyperthermia Agent in Biomedicines.

In this study, the ac magnetic hyperthermia responses of spinel CoFe₂O₄, MnFe₂O₄, and NiFe₂O₄ nanoparticles of comparable sizes (∼20 nm) were investigated to evaluate their feasibility of use in magnetic hyperthermia. The heating ability of EDT-coated nanoparticles which were dispersed in two different carrier media, deionized water and ethylene glycol, at concentrations of 1 and 2 mg/mL, was evaluated by estimating the specific loss power (SLP) (which is a measure of magnetic energy transformed into heat) under magnetic fields of 15, 25, and 50 kA/m at a constant frequency of 195 kHz. The maximum value of SLP has been found to be ∼315 W/g for CoFe₂O₄ and ∼295 W/g for MnFe₂O₄ and NiFe₂O₄ nanoparticles. We report very promising heating temperature rising characteristics of CoFe₂O₄, MnFe₂O₄, and NiFe₂O₄ nanoparticles under different applied magnetic fields that indicate the effectiveness of these nanoparticles as hyperthermia agents.