Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.
Słowa kluczowe
Abstrakcyjny
Microvascular permeability of macromolecules in normal and tumor tissues was measured under hyperthermic conditions. Fluorescein-isothiocyanate tagged dextran (150,000 molecular weight) was chosen as a tracer substance. The modified Sandison type rabbit ear chamber was used to study transport in normal (mature granulation) tissue and tumor (VX2 carcinoma) tissue. Hyperthermia (43 degrees C and 50 degrees C for one hour) was induced with a precision thermal water bath attached to the chamber. When heated to 43 degrees C, the normal tissue microvascular permeability increased to 9.4 +/- 7.3 X 10(-8) cm/s, but not statistically different from the control value of 7.3 +/- 3.3 X 10(-8) cm/s. When heated to 50 degrees C, the normal tissue microvascular permeability rose about six-fold to 44.4 +/- 35.3 X 10(-8) cm/s (p less than 0.01). When heated to 43 degrees C, the tumor microvascular permeability increased to 89.4 +/- 29.7 X 10(-8) cm/s, but not statistically different from the control value of 57.3 +/- 39.2 X 10(-8) cm/s. However, when the tumor tissue was heated to 50 degrees C, its permeability nearly doubled to 112.2 +/- 20.8 X 10(-8) cm/s (p less than 0.025).