Lipid profile and fat patterning in children at a mean of 8.8 years after Kawasaki disease: a study from Northern India.

OBJECTIVE

Kawasaki disease (KD) is an acute vasculitis that can result in coronary artery abnormalities (CAA). Higher risk of atherosclerosis has also been documented in those who do not develop CAA. We report herein the lipid profile and fat patterning in children with KD in a cohort from Northern India at a mean follow-up of 8.8 years after the acute stage. There is a paucity of literature on this aspect of KD.

METHODS

Twenty children, who had developed KD at least 5 years previously were enrolled along with age- and sex-matched controls. Cases and controls underwent anthropometric assessment using standardised techniques and instruments. Lipids were assayed only in the cases.

RESULTS

There was no significant difference in weight, height, mid-upper arm circumference, waist circumference, hip circumference and waist-to-hip ratio between cases and controls. Skinfold thickness (ST) at triceps, subscapular, midaxillary and suprailiac regions was similar in cases and controls. Biceps and medial calf ST was, however, significantly higher among girls with KD in 10-14.9 years age group. On comparison with cut-offs enumerated by the National Cholesterol Education Program (NCEP), 2 children with KD had borderline while 1 had undesirable levels of total cholesterol. Undesirable triglyceride levels were seen in 12 children. Ten children had HDL levels <35 mg/dl while 1 had borderline LDL levels.

CONCLUSIONS

Lipid abnormalities at a mean of 8.8 years after KD suggest that these patients may be prone to premature atherosclerosis. There were no significant differences in the anthropometric parameters and most of the ST.