Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants.
Słowa kluczowe
Abstrakcyjny
BACKGROUND
Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures.
OBJECTIVE
To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers.
METHODS
In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models.
RESULTS
Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated.
CONCLUSIONS
Different biomarkers of oxidative stress may reflect different biological processes.
