[Study on effect of acupoint sticker of TTS-ST93-1 in treating motion sickness].

OBJECTIVE

To observe the effect of Transdermal Therapeutic System ST93-1 (TTS-ST93-1) by acupoint sticking in treating motion sickness (MS).

METHODS

One hundred and sixty-three young volunteers with history of MS recently were subjected to a 3 hours journey by track and armored car, and divided randomly into tested, positive control and negative control groups, treated with TTS-ST93-1 plaster, TTS-Scopolamine plaster and placebo (lactose plaster) respectively. The TTS-ST93-1 plaster was stuck on Neiguan (P6) or Shenque (CV8) or Qimai (TE18) point and the effect of treatment was observed by double-blind method.

RESULTS

The mean effective rate of tested group was 95.9%, which was significantly different to that of the negative control group (P < 0.01). In the tested group, the protection rate of plaster stuck on Shenque was 81.4%, on Neiguan was 45.5% and on Qimai was 100%, with an average of 76.0%, which was significantly different to that of the negative control group. The protection rate of TTS-Scopolamine plaster was merely 27.3%. The side effects of TTS-ST93-1 plaster were mouth dryness, sleepiness and fatigue, as compared with the negative control group, the difference was insignificant. No allergic reaction of skin such as swelling, pain or itching was found in the tested group.

CONCLUSIONS

Acupoint sticker of TTS-ST93-1 was an effective treatment for MS with less side effect and no allergic reaction of skin.