Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 2011-Aug
[Study on the activated fraction with proliferation and apoptosis effect on T lymphocyte of Celastrus aculeatus].
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OBJECTIVE
To screen the activated fraction from Celastrus aculeatus and study its effect on T lymphocyte apoptosis.
METHODS
Different polarity fractions were isolated from Celastrus aculeatus extract. Flow Cytometry method was used to detect apoptosis ratio of the active fractions.
RESULTS
Different fractions extract from Celastrus aculeatus and GSF-A could significantly inhibit T lymphocyte proliferation and induce T lymphocyte apoptosis.
CONCLUSIONS
The activated fractions isolated from Celastrus aculeatus have anti-inflammatory effect. Its mechanism may be related to the apoptosis effect on T lymphocyte.
