[The role of the leukocytes in the mast cell reaction in an inflammatory focus].

Models of acute infectious and aseptic peritonitis in rats with vinblastine-induced leukopenia have shown the regulatory influence of leukocytes on mast cells consisting in antimicrobic and activating effects. While infectious inflammation is characterized by increased mast cell degranulation both before and after marked leukocyte accumulation in the inflammatory focus and blood. Aseptic inflammation is followed by retardation of mast cell reaction to the significant leukocyte influx into inflammatory focus and blood and increased mast cell degranulation after leukocyte influx.