The triterpenoid fraction from Trichosanthes dioica root suppresses experimentally induced inflammatory ascites in rats.
Słowa kluczowe
Abstrakcyjny
BACKGROUND
Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English, is a dioecious climber found wild throughout the plains of the Indian subcontinent and traditionally used in India for several medicinal purposes.
OBJECTIVE
The present study evaluated the protective effect of the triterpenoid enriched fraction from T. dioica root (CETD) against experimentally induced acute inflammatory ascites in Wistar albino rats.
METHODS
The CETD was administered orally at the different doses (25, 50 and 100 mg/kg body weight) to overnight fasted rats, and then ascites was induced by intraperitoneal administration of formalin solution. After 7 h, the rats were sacrificed and the volume of ascitic fluid was measured.
RESULTS
The CETD demonstrated significant (p < 0.01) reduction of ascitic fluid formation in a dose-dependent manner as compared with control.
CONCLUSIONS
The CETD produced significant and dose-dependent inhibition of experimentally induced inflammatory ascites in Wistar albino rats.
