Polish
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
Thyroid 2020-Mar

Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone Induced Cardiac Hypertrophy and Pyrexia.

Tylko zarejestrowani użytkownicy mogą tłumaczyć artykuły
Zaloguj się Zarejestruj się
Link zostanie zapisany w schowku
Beate Herrmann
Lisbeth Harder
Rebecca Oelkrug
Jiesi Chen
Sogol Gachkar
Sebastian Nock
Julia Resch
Markus Korkowski
Heike Heuer
Jens Mittag

Słowa kluczowe

Abstrakcyjny

Tachycardia, cardiac hypertrophy and elevated body temperature are major signs of systemic hyperthyroidism, which are considered to reflect the excessive thyroid hormone (TH) action in the respective peripheral tissues. However, recent observations indicate that the central actions of TH also contribute substantially to cardiovascular regulation and thermogenesis.Here, we dissect the individual contributions of peripheral TH action versus the central contribution in body temperature regulation and cardiovascular functions by taking advantage of mice lacking the TH transporters MCT8 and OATP1C1 (M/O dko), which exhibit elevated serum T3 levels while their brain is in a profoundly hypothyroid state. We compared these animals to wildtype mice that were treated orally with T3 to achieve similarly elevated serum T3 levels, but do not exhibit central hypothyroidism. For the studies we used radiotelemetry, infrared thermography, gene expression profiling, Western blot, and ELISA assays.Our analyses revealed mild hyperthermia and cardiac hypertrophy in T3-treated wildtype mice but not in M/O dko animals, suggesting that central actions of TH are required for these hyperthyroid phenotypes. Although the average heart rate was unaffected in either model, the M/O dko exhibited an altered heart rate frequency distribution with tachycardic bursts in active periods and bradycardic episodes during resting time, demonstrating that the stabilization of heart rate by the autonomic nervous system can be impaired in these centrally hypothyroid animals.Our studies unravel distinct phenotypical traits of hyperthyroidism that depend on an intact central nervous system, and provide valuable insight into the cardiovascular pathology of the Allan-Herndon-Dudley Syndrome, a condition caused by the lack of MCT8 in humans.

Dołącz do naszej strony
na Facebooku

Najbardziej kompletna baza danych ziół leczniczych poparta naukowo

  • Działa w 55 językach
  • Ziołowe leki poparte nauką
  • Rozpoznawanie ziół na podstawie obrazu
  • Interaktywna mapa GPS - oznacz zioła na miejscu (wkrótce)
  • Przeczytaj publikacje naukowe związane z Twoim wyszukiwaniem
  • Szukaj ziół leczniczych po ich działaniu
  • Uporządkuj swoje zainteresowania i bądź na bieżąco z nowościami, badaniami klinicznymi i patentami

Wpisz objaw lub chorobę i przeczytaj o ziołach, które mogą pomóc, wpisz zioło i zobacz choroby i objawy, na które są stosowane.
* Wszystkie informacje oparte są na opublikowanych badaniach naukowych

Google Play badgeApp Store badge