A surface treated intraocular lens implant for use in the replacement of a cataracts natural lens to prevent posterior cellular opacification. The surface treated intraocular lens includes one or more carbohydrates covalently bound to the surface of the intraocular lens implant and a carbohydrate binding agent conjugated to a cytotoxic agent for binding said carbohydrates. The cytotoxic agent present on the intraocular lens implant serves to destroy residual lens epithelial cells within the lens capsule thereby preventing posterior cellular opacification of the intraocular lens implant.

Bausch &amp; Lomb Surgical, Inc.

Intraocular lens implants for the prevention of secondary cataracts

The invention relates to the technical application of electromagnetic radiation such as microwaves and radiowaves and application of ultra sound to chain molecules. In particular, the present invention relates to the utilization of topological excitations such as wring, twist and torsional modes, e.g., for generating structure, such as in folding, refolding or renaturation, and denaturation or unfolding of peptides, polypeptides, proteins, and enzymes; for generating changes in molecular affinity; for stimulating drug receptor interactions; and for changing molecular communication, is described. The technique is based on a new understanding of the underlying physical phenomenon and can also be applied to other chain molecules and biologically active biomolecules and tailored polymers such as glucoproteins, antibodies, genomic chain molecules such as DNA and RNA as well as PNA, carbohydrates, and synthetic and natural organic polymers. The invention is especially applicable for solving problems related to inclusion bodies and aggregation when using recombinant DNA and protein engineering techniques. Furthermore, the invention can be utilized in therapeutic treatment and in development and production of pharmaceuticals. The area of applicability ranges from biotechnological industry, food industry, drug industry, pharmacological industry, chemical industry, and concerns, e.g., the treatment of conditions and diseases related to influenza, hepatitis, polio, malaria, borrelia, diabetes, Alzheimer's disease, Creutzfeldt Jakob disease, other prion related diseases, multiple sclerosis, cataract, heart diseases, cancer, and aging.

cataract/carbohydrate

Intraocular lens implants for the prevention of secondary cataracts

Resonance driven changes in chain molecule structure

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