Citrulline genration test before starting enteral nutrition
At ICU admission, a blood sample is collected (i) before and (ii) 90 minutes after N2-L-Alanyl-L-Glutamine administration

Enteral Nutrition

Intensive Care Unit

Biomarkers

20 gr of 10% N2-L-Alanyl-L-Glutamine, dilution in 200 ml of water for injection, intravenous perfusion over 30 minutes

N2-L-Alanyl-L-Glutamine (Substance)

Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients

Feeding intolerance evaluated at day-3 of enteral nutrition Citrulline generation test: variation of citrullinemia/90 minutes

Feeding intolerance at day-3 of enteral nutrition Citrullinemia measured the first day just before initiation of enteral nutrition

Link between citrullinemia and cumulative amount of enteral nutrition administred during the first three days of ICU stay

Link between citrullinemia levels and occurrence of acute mesenteric ischemia and inhalation pneumopathy during the first week of enteral nutrition

Centre Hospitalier Universitaire de Besancon

A bolus of Dipeptiven (Glutamine-Alanine) administered intravenously over 30 minute (20 gramme of N2-L-Alanyl-L-Glutamine solution, dilution in 200 ml of water for injection, intravenous perfusion over 30 minutes).

Drug: FE 203799 Drug: BEAM Procedure: myeloablative chemotherapy Procedure: autologous stem cell transplantation

Lymphoma, Non-Hodgkin's, Adult

Lymphoma, Hodgkin's, Adult

GLP-2 analogue, once weekly, subcutaneous administration

FE 203799

Safety, Tolerability, PK/PD of FE 203799 in Adults With Lymphomas

Double-blind, Placebo Controlled, Ascending Dose, Randomized Phase 1B/2A Study, Investigating Safety, Tolerability, PK/PD of FE 203799 in Lymphoma Patients, Undergoing Myeloablative Chemotherapy Before Autologous Transplantation

Adverse events as assessed by CTCAE v4.03

Plasma concentration of citrulline (ng/ml)

Plasma concentration of C-Reactive Protein (ng/ml)

Development of fever when absolute neutrophil count (ANC) ≤ 0.5 x 109 and body temperature ≥ 38.2 ◦C for two consecutive values over a 30 minute period of time; or ANC < 0.5 x 109 and body temperature ≥ 38.5◦C at any single timepoint

Gastrointestinal damage assessed by the Lewis Score; this is evaluation of villous edema, ulcers and stenosis graded collectively; Normal < 135, Mild 135-790, Moderate - severe ≥790

Assessment of duration of parenteral nutrition (L)

Determination of microbial populations by genomic analysis (relative abundance of taxonomic levels)

Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) questionnaire

citrulline/wymioty

Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients

Safety, Tolerability, PK/PD of FE 203799 in Adults With Lymphomas

Natural History and Pathophysiology of Gastrointestinal Graft-versus-Host Disease

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