fullterm/ preterm neonates hospitalized in NICU with suspect of sepsis

Sepsis

performed with blood culture simultaneously

molecular assay

performed with molecular assay simultaneously

Blood culture

Neonatal Unit, IRCCS Policlinico S. Matteo.

Neonatal Sepsis Diagnosis: ; PCR Commercial Technique and Blood Culture

PCR Technique of a Commercial Test and Blood Culture to Early Detect Sepsis in NICU

to verify the frequency of positive test (neonatal sepsis, EOS or LOS) detected by the molecular assay compare to these of the blood culture

Lidia Decembrino

IRCCS Policlinico S. Matteo

Children included in the INIS trial in whom pathogenic organisms (i.e. bacteria or fungi) were cultured from blood and/or cerebrospinal fluid during the sepsis period at the time of study inclusion

Children included in the INIS trial in whom no pathogenic organisms (i.e. bacteria or fungi) were cultured from blood or cerebrospinal fluid during the sepsis period at the time of study inclusion

Neonatal Sepsis

Proven sepsis

Neurodevelopmental Outcomes After Suspected or Proven Sepsis: Secondary Analysis of INIS Trial Database

Death or major disability at two years of age. The diagnosis of major disability was based on the answers to questions on the HSQ or the PQ [see Study Description and INIS Collaborative Group 2011 (online supplement) for more detail]. If the domain classification was unknown and a SHSQ had been received, the classification from that questionnaire was used for that domain only.

Disability at two years of age, categorised as major or non-major. The diagnosis of disability was based on the answers to questions on the HSQ or the PQ [see Study Description and INIS Collaborative Group 2011 (online supplement) for more detail]. If the domain classification was unknown and a SHSQ had been received, the classification from that questionnaire was used for that domain only.

Disability due to seizures at two years of age, categorised as major or non-major. The diagnosis of disability due to seizures was based on the answers to questions on the HSQ or the PQ [see Study Description and INIS Collaborative Group 2011 (online supplement) for more detail]. If the domain classification was unknown and a SHSQ had been received, the classification from that questionnaire was used.

Hearing disability at two years of age, categorised as major or non-major. The diagnosis of hearing disability was based on the answers to questions on the HSQ or the PQ [see Study Description and INIS Collaborative Group 2011 (online supplement) for more detail]. If the domain classification was unknown and a SHSQ had been received, the classification from that questionnaire was used.

Visual disability at two years of age, categorised as major or non-major. The diagnosis of visual disability was based on the answers to questions on the HSQ or the PQ [see Study Description and INIS Collaborative Group 2011 (online supplement) for more detail]. If the domain classification was unknown and a SHSQ had been received, the classification from that questionnaire was used.

Communicative disability at two years of age, categorised as major or non-major. The diagnosis of communicative disability was based on the answers to questions on the HSQ or the PQ [see Study Description and INIS Collaborative Group 2011 (online supplement) for more detail]. If the domain classification was unknown and a SHSQ had been received, the classification from that questionnaire was used.

Cognitive disability at two years of age, categorised as major or non-major. The diagnosis of cognitive disability was based on PARCA-R1 [Saudino 1998], as described previously [INIS Collaborative Group 2011 (online supplement)]

Neuromotor disability at two years of age, categorised as major or non-major. The diagnosis of neuromotor disability was based on the answers to questions on the HSQ or the PQ [see Study Description and INIS Collaborative Group 2011 (online supplement) for more detail]. If the domain classification was unknown and a SHSQ had been received, the classification from that questionnaire was used.

coagulase/napad padaczkowy

Neonatal Sepsis Diagnosis: ; PCR Commercial Technique and Blood Culture

Neurodevelopmental Outcomes After Suspected or Proven Sepsis: Secondary Analysis of INIS Trial Database

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